SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2021
Local antibiotics in primary hip and knee arthroplasty: a systematic review and meta-analysis.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Intrawound vancomycin powder for prevention of surgical site infections in primary joint arthroplasty: an umbrella review of systematic reviews and meta-analyses.International journal of surgery (London, England) · 2025Pooled it
- Analysis of the Need for Postoperative Drainage Application for Hip Arthroplasty: A Systematic Review and Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Review
- Impact of Antibiotic Bone Cement on Infection Rates in Primary Total Knee Arthroplasty: A GRADE-Assessed Systematic Review and Meta-Analysis of Observational Studies Involving Over 4 Million Patients.Open forum infectious diseases · 2026Review
- INFECTION PROFILE IN HIP ARTHROPLASTY AT A REFERRAL HOSPITAL.Acta ortopedica brasileira · 2026Article
- The Role of Intrawound Vancomycin Powder in Reducing Surgical Site Infections in Orthopedic Surgery: A Comprehensive Narrative Review of Its Efficacy, Safety, and Applications.Indian journal of orthopaedics · 2025Review
- Efficacy and safety of vancomycin for local application in the prevention of surgical site infection after joint arthroplasty: a systematic review and meta-analysis.EFORT open reviews · 2024Article
- The effect of different preventive strategies during total joint arthroplasty on periprosthetic joint infection: a network meta-analysis.Journal of orthopaedic surgery and research · 2024Article
- Periprosthetic Joint Infection After Total Knee Arthroplasty With or Without Antibiotic Bone Cement.JAMA network open · 2024Article
- [Importance of local antibiotics in the prophylaxis and treatment of fracture-associated infections].Unfallchirurgie (Heidelberg, Germany) · 2024Review
- Surgical site application of antibiotics: A potential game changer for fracture-related infection care and antibiotic stewardship.Journal of orthopaedics · 2023Article
- Use of topical vancomycin powder in total joint arthroplasty: Why the current literature is inconsistent?World journal of orthopedics · 2023Review
- Observational
- Locally delivered antistaphylococcal lysin exebacase or CF-296 is active in methicillin-resistantJournal of bone and joint infection · 2022Article
- The Prospective Randomized EValuation of Emerging Novel Treatments for Infection Prophylaxis in Total Joint Replacement (PREVENT-iT): Feasibility and Safety Study.JB & JS open accessArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInfection is a truly devastating complication of total joint arthroplasty, causing most patients to undergo a revision surgery, and to bear significant psychological and financial burden. The purpose of this study is to systematically evaluate the literature to determine the efficacy and complication profile of local antibiotic application in primary total joint arthroplasty.
methodsAll studies of primary total joint arthroplasty which assessed local antibiotics in any form other than antibiotic-impregnated cement as an intervention were included. Studies that reported at least one outcome related to infection and were available in full text in English were eligible for inclusion. Studies which included both primary and revision cases but did not report the stratified data for each type of surgery and studies on fracture populations were excluded.
resultsA total of 9 studies involving 3,714 cases were included. The pooled deep infection rate was 1.6% in the intervention groups and 3.5% in the control groups. Meta-analysis revealed a RR of 0.53 (95%CI: 0.35-0.79, p = 0.002) with no heterogeneity (I
conclusionLocal antibiotic application results in a moderate reduction in deep infection rates in primary total joint arthroplasty, with no significant impact on superficial infection rates. However, local antibiotic application may be associated with a moderate increase in aseptic wound complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.