Evidence map›Paper›PMID 33104797›Full record

ArticleNucleic acids research2021

REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments.

Luigi Mansi, Marco Antonio Tangaro, Claudio Lo Giudice, Tiziano Flati, Eli Kopel, Amos Avraham Schaffer, Tiziana Castrignanò, Giovanni Chillemi, Graziano Pesole, Ernesto Picardi

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 106 papers.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 205 citations in OpenAlex.

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  8. Multi-Tissue Genetic Regulation of RNA Editing in Pigs.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Luigi MansiDepartment of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy.
Marco Antonio TangaroInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies (IBIOM), National Research Council, Via Amendola 122/O, 70126 Bari, Italy.
Claudio Lo GiudiceDepartment of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy.
Tiziano FlatiSCAI-Super Computing Applications and Innovation Department, CINECA, Via dei Tizii 6B, 00185 Rome, Italy.
Eli KopelMina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900 Ramat Gan, Israel.
Amos Avraham SchafferMina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, 52900 Ramat Gan, Israel.
Tiziana CastrignanòDepartment of Ecological and Biological Sciences (DEB), University of Tuscia, Via S. Camillo de Lellis 44, 01100 Viterbo, Italy.
Giovanni ChillemiDepartment for Innovation in Biological, Agro-food and Forest systems (DIBAF), University of Tuscia, Via S. Camillo de Lellis 44, 01100 Viterbo, Italy.
Graziano PesoleDepartment of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy.
Ernesto PicardiDepartment of Biosciences, Biotechnologies and Biopharmaceutics (DBBB), University of Bari, Via Orabona 4, 70125 Bari, Italy.
Bar-Ilan University · ILIstituto Nazionale Biostrutture e Biosistemi · ITUniversità degli Studi della Tuscia · ITUniversity of Bari Aldo Moro · ITInstitute of Biomembranes, Bioenergetics and Molecular Biotechnologies · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary transcripts. RNA editing has pivotal roles in the regulation of gene expression or modulation of the innate immune response or functioning of several neurotransmitter receptors. Massive transcriptome sequencing has fostered the research in this field. Nonetheless, different aspects of the RNA editing biology are still unknown and need to be elucidated. To support the study of A-to-I RNA editing we have updated our REDIportal catalogue raising its content to about 16 millions of events detected in 9642 human RNAseq samples from the GTEx project by using a dedicated pipeline based on the HPC version of the REDItools software. REDIportal now allows searches at sample level, provides overviews of RNA editing profiles per each RNAseq experiment, implements a Gene View module to look at individual events in their genic context and hosts the CLAIRE database. Starting from this novel version, REDIportal will start collecting non-human RNA editing changes for comparative genomics investigations. The database is freely available at http://srv00.recas.ba.infn.it/atlas/index.html.

Indexed as

Databases, GeneticGene Expression RegulationBase SequenceComputational BiologyData CurationData MiningGene Expression ProfilingGenomicsHumansInternetProteomeProteomicsRNA EditingTranscriptomeProteome

Identifiers

PMID33104797
PMCPMC7778987
OpenAlexW3094586730

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.