Evidence map›Paper›PMID 33104772›Full record

ArticleNucleic acids research2021

The mouse Gene Expression Database (GXD): 2021 update.

Richard M Baldarelli, Constance M Smith, Jacqueline H Finger, Terry F Hayamizu, Ingeborg J McCright, Jingxia Xu, David R Shaw, Jonathan S Beal, Olin Blodgett, Jeffrey Campbell and 7 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed
6.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 163 citations in OpenAlex.

  1. FASEB bioAdvances · 2026
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  3. NovelVeterinary and animal science · 2026
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  6. Contrasting the genetic architecture of cardiac glutathione against other organs: unveiling a unique tissue-specific locus.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Harmonizing mouse anatomy terminology: a common language?Mammalian genome : official journal of the International Mammalian Genome Society · 2025
    Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Richard M BaldarelliThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Constance M SmithThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Jacqueline H FingerThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Terry F HayamizuThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Ingeborg J McCrightThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Jingxia XuThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
David R ShawThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Jonathan S BealThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Olin BlodgettThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Jeffrey CampbellThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Lori E CorbaniThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Pete J FrostThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Sharon C GiannattoThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Dave B MiersThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
James A KadinThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Joel E RichardsonThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Martin RingwaldThe Jackson Laboratory, 600 Main Street, Bar Harbor, ME 04609, USA.
Jackson Laboratory · US

Funding

Technical DevelopmentP41HD062499 · NICHD · JACKSON LABORATORY · PI MARTIN RINGWALD · 2011 to 2026
$37.3M
NICHD NIH HHS P41 HD062499
6 · The paper itself

Abstract

The Gene Expression Database (GXD; www.informatics.jax.org/expression.shtml) is an extensive and well-curated community resource of mouse developmental gene expression information. For many years, GXD has collected and integrated data from RNA in situ hybridization, immunohistochemistry, RT-PCR, northern blot, and western blot experiments through curation of the scientific literature and by collaborations with large-scale expression projects. Since our last report in 2019, we have continued to acquire these classical types of expression data; developed a searchable index of RNA-Seq and microarray experiments that allows users to quickly and reliably find specific mouse expression studies in ArrayExpress (https://www.ebi.ac.uk/arrayexpress/) and GEO (https://www.ncbi.nlm.nih.gov/geo/); and expanded GXD to include RNA-Seq data. Uniformly processed RNA-Seq data are imported from the EBI Expression Atlas and then integrated with the other types of expression data in GXD, and with the genetic, functional, phenotypic and disease-related information in Mouse Genome Informatics (MGI). This integration has made the RNA-Seq data accessible via GXD's enhanced searching and filtering capabilities. Further, we have embedded the Morpheus heat map utility into the GXD user interface to provide additional tools for display and analysis of RNA-Seq data, including heat map visualization, sorting, filtering, hierarchical clustering, nearest neighbors analysis and visual enrichment.

Indexed as

Databases, GeneticGene ExpressionAnimalsCluster AnalysisGene Expression ProfilingHigh-Throughput Nucleotide SequencingInternetMiceProteinsUser-Computer InterfaceProteins

Identifiers

PMID33104772
PMCPMC7778941
OpenAlexW3093887756

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.