Evidence map›Paper›PMID 33104495›Full record

SynthesisUnited European gastroenterology journal2021

Sample-size estimation is not reported in 24% of randomised controlled trials of inflammatory bowel disease: A systematic review.

Zipporah Iheozor-Ejiofor, Svetlana Lakunina, Morris Gordon, Daniel Akintelure, Vasiliki Sinopoulou, Anthony Akobeng

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in United European gastroenterology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 10 syntheses or guidelines pooled it.

  1. Guideline
  2. Pooled it
  3. Prebiotics for induction and maintenance of remission in ulcerative colitis.The Cochrane database of systematic reviews · 2024
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Infliximab for medical induction of remission in Crohn's disease.The Cochrane database of systematic reviews · 2023
    Pooled it
  7. Vitamin D for the treatment of inflammatory bowel disease.The Cochrane database of systematic reviews · 2023
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Pooled it
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Medical treatment of eosinophilic esophagitis.The Cochrane database of systematic reviews · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zipporah Iheozor-EjioforCentre for Biostatistics, University of Manchester, Manchester, UK.
Svetlana LakuninaBiomedical Evidence Synthesis and Translation to Practice (BEST) Research Unit, School of Medicine, University of Central Lancashire, National Institute of Health Research, Preston, UK.ORCID 0000-0002-3180-6336
Morris GordonBiomedical Evidence Synthesis and Translation to Practice (BEST) Research Unit, School of Medicine, University of Central Lancashire, National Institute of Health Research, Preston, UK.
Daniel AkintelureBiomedical Evidence Synthesis and Translation to Practice (BEST) Research Unit, School of Medicine, University of Central Lancashire, National Institute of Health Research, Preston, UK.
Vasiliki SinopoulouBiomedical Evidence Synthesis and Translation to Practice (BEST) Research Unit, School of Medicine, University of Central Lancashire, National Institute of Health Research, Preston, UK.
Anthony AkobengDepartment of Gastroenterology, Sidra Medical Centre, Ar-Rayyan, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSample-size estimation is an important factor in designing a clinical trial. A recent study found that 65% of Cochrane systematic reviews had imprecise results.

objectiveThis study set out to review the whole body of inflammatory bowel disease (IBD) randomised controlled trials systematically in order to identify the reporting of sample-size estimation.

methodsWe conducted a comprehensive hand search of the Cochrane Library and Cochrane IBD Specialized Trials Register. We extracted information on relevant features and the results of the included studies. We produced descriptive statistics for our results.

resultsA total of 242 randomised controlled trials were included from 44 Cochrane systematic reviews. About 25% of the studies failed to report on sample-size estimation. Of those that did report on sample-size estimation, 33% failed to recruit their target sample size.

conclusionsAround half of the randomised controlled trials in IBD either do not report sample-size estimation or reach their recruitment target with the level of detail in reporting being limited.

Indexed as

Inflammatory Bowel DiseasesSample SizeHumansRandomized Controlled Trials as TopicCrohn's diseasegastroenterologyIBDinflammatory bowel diseasesulcerative colitis

Identifiers

PMID33104495
PMCPMC8259284

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.