ArticleMultiple sclerosis (Houndmills, Basingstoke, England)2021
Increased functional sensorimotor network efficiency relates to disability in multiple sclerosis.
Article in Multiple sclerosis (Houndmills, Basingstoke, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Spatial gene expression and functional network abnormalities in multiple sclerosis: exploring biological influence on brain functional reorganization.Translational psychiatry · 2026Article
- Changes in functional connectivity in relapsing-remitting multiple sclerosis spinal cord measured via region-based and data-driven analyses.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Functional gradients reveal cortical hierarchy changes in multiple sclerosis.Human brain mapping · 2024Article
- Higher-order functional connectivity analysis of resting-state functional magnetic resonance imaging data using multivariate cumulants.Human brain mapping · 2024Article
- Don't be late! Postponing cognitive decline and preventing early unemployment in people with multiple sclerosis: a study protocol.BMC neurology · 2024Article
- Resting-state functional MRI in multicenter studies on multiple sclerosis: a report on raw data quality and functional connectivity features from the Italian Neuroimaging Network Initiative.Journal of neurology · 2023Article
- Increased flexibility of brain dynamics in patients with multiple sclerosis.Brain communications · 2023Article
- Sensorimotor network dynamics predict decline in upper and lower limb function in people with multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2023Article
- Male and female are not the same: a multicenter study of static and dynamic functional connectivity in relapse-remitting multiple sclerosis in China.Frontiers in immunology · 2023Article
- Lymphotoxin-alpha expression in the meninges causes lymphoid tissue formation and neurodegeneration.Brain : a journal of neurology · 2022Article
- Anatomical and functional visual network patterns in progressive multiple sclerosis.Human brain mapping · 2022Article
- A more unstable resting-state functional network in cognitively declining multiple sclerosis.Brain communications · 2022Article
- Functional connectivity in the dorsal network of the cervical spinal cord is correlated with diffusion tensor imaging indices in relapsing-remitting multiple sclerosis.NeuroImage. Clinical · 2022Article
- The network collapse in multiple sclerosis: An overview of novel concepts to address disease dynamics.NeuroImage. Clinical · 2022Review
- Motor Imagery of Walking in People Living with and without Multiple Sclerosis: A Cross-Sectional Comparison of Mental Chronometry.Brain sciences · 2021Article
- The constrained brain in multiple sclerosis: Cognitive impairment is related to network-specific coupling of structural and functional connectivity.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNetwork abnormalities could help explain physical disability in multiple sclerosis (MS), which remains poorly understood.
objectiveThis study investigates functional network efficiency changes in the sensorimotor system.
methodsWe included 222 MS patients, divided into low disability (LD, Expanded Disability Status Scale (EDSS) ⩽3.5,
resultsHD patients demonstrated significantly higher LE of the left primary somatosensory cortex (S1) and right pallidum compared to LD and HC, and left premotor cortex compared to HC only. The logistic regression model for disability (
conclusionClinical disability in MS associates with functional sensorimotor increases in efficiency and connectivity, centred around S1, independent of structural damage.
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