ArticleAngewandte Chemie (International ed. in English)2021
Controlling Optical and Catalytic Activity of Genetically Engineered Proteins by Ultrasound.
Article in Angewandte Chemie (International ed. in English), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Piezoelectric Nanozymes With Acoustically Rejuvenated Catalytic Activities Rewire Lipid Metabolism for Two-Pronged Ferroptotic Therapy.Angewandte Chemie (International ed. in English) · 2026Article
- The mechanochemical activation of a pyrimidine dimer.Chemical science · 2026Article
- Stimuli-Responsive Supramolecular Biomaterials for Cancer Theranostics.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Low-intensity pulsed ultrasound treatment in erectile dysfunction.Asian journal of andrology · 2025Review
- Remote Control of Eukaryotic Gene Expression by a Modular Ultrasound-Responsive RNA Toolkit.Angewandte Chemie (International ed. in English) · 2025Article
- Mechanochemistry: Fundamental Principles and Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- A comprehensive review of advanced focused ultrasound (FUS) microbubbles-mediated treatment of Alzheimer's disease.Heliyon · 2024Review
- Accelerated Mechanophore Activation and Drug Release in Network Core-Structured Star Polymers Using High-Intensity Focused Ultrasound.Small science · 2024Article
- Mechanically Active Supramolecular Systems.Small science · 2024Article
- Shape morphing of hydrogels by harnessing enzyme enabled mechanoresponse.Nature communications · 2024Article
- The principles and promising future of sonogenetics for precision medicine.Theranostics · 2024Review
- Force-Triggered Atropisomerization of a Parallel Diarylethene to Its Antiparallel Diastereomers.Journal of the American Chemical Society · 2023Article
- Nanopore Detection Using Supercharged Polypeptide Molecular Carriers.Journal of the American Chemical Society · 2023Article
- Mechanoresponsive diselenide-crosslinked microgels with programmed ultrasound-triggered degradation and radical scavenging ability for protein protection.Chemical science · 2022Article
- Recent advances in mechanical force-responsive drug delivery systems.Nanoscale advances · 2022Review
- Force ahead: Emerging Applications and Opportunities of Polymer Mechanochemistry.ACS polymers Au · 2022Article
- Accelerated Mechanochemistry in Helical Polymers.Angewandte Chemie (International ed. in English) · 2022Article
- Ultrasound-Responsive Systems as Components for Smart Materials.Chemical reviews · 2022Review
- Ultrasound-controlled drug release and drug activation for cancer therapy.Exploration (Beijing, China) · 2021Review
- Tailoring the Properties of Optical Force Probes for Polymer Mechanochemistry.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ultrasound (US) produces cavitation-induced mechanical forces stretching and breaking polymer chains in solution. This type of polymer mechanochemistry is widely used for synthetic polymers, but not biomacromolecules, even though US is biocompatible and commonly used for medical therapy as well as in vivo imaging. The ability to control protein activity by US would thus be a major stepping-stone for these disciplines. Here, we provide the first examples of selective protein activation and deactivation by means of US. Using GFP as a model system, we engineer US sensitivity into proteins by design. The incorporation of long and highly charged domains enables the efficient transfer of force to the protein structure. We then use this principle to activate the catalytic activity of trypsin by inducing the release of its inhibitor. We expect that this concept to switch "on" and "off" protein activity by US will serve as a blueprint to remotely control other bioactive molecules.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.