Evidence map›Paper›PMID 33104252›Full record

ArticleThe Journal of pathology2021

Distinct contributions of cathelin-related antimicrobial peptide (CRAMP) derived from epithelial cells and macrophages to colon mucosal homeostasis.

Keqiang Chen, Teizo Yoshimura, Xiaohong Yao, Wanghua Gong, Jiaqiang Huang, Amiran K Dzutsev, John McCulloch, Colm O'hUigin, Xiu-Wu Bian, Giorgio Trinchieri and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Colon mucus in colorectal neoplasia and beyond.World journal of gastroenterology · 2022
    Review
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 3 countries.

Keqiang ChenCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Teizo YoshimuraDepartment of Pathology and Experimental Medicine, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
Xiaohong YaoInstitute of Pathology and Southwest Cancer Center, Third Military Medical University, Chongqing, PR China.
Wanghua GongBasic Research Program, Leidos Biomedical Research, Inc, Frederick, MD, USA.
Jiaqiang HuangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Amiran K DzutsevCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
John McCullochCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Colm O'hUiginCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Xiu-Wu BianInstitute of Pathology and Southwest Cancer Center, Third Military Medical University, Chongqing, PR China.ORCID 0000-0003-4383-0197
Giorgio TrinchieriCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Ji Ming WangCancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, MD, USA.
Frederick National Laboratory for Cancer Research · USArmy Medical University · CNBeijing Jiaotong University · CNLeidos (United States) · USOkayama University · JP

Funding

LICI Microbiome and Genetics CoreZICBC011237 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI OHUIGIN, COLM · 2009 to 2025
$28.3M
Role of mouse microbiome in cancer and inflammationZIABC011153 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$22.0M
Role of inflammation, innate resistance, and immunity in carcinogenesis.ZIABC010793 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI TRINCHIERI, GIORGIO · 2009 to 2025
$16.8M
Role of Formylpeptide Receptors in Host DefenseZIABC010725 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI WANG, JI MING · 2009 to 2023
$6.3M
Federal funds from the National Cancer Institute (NCI), National Institutes of Health (NIH) HSN261200800001E
6 · The paper itself

Abstract

The cathelin-related antimicrobial peptide CRAMP protects the mouse colon from inflammation, inflammation-associated carcinogenesis, and disrupted microbiome balance, as shown in systemic Cnlp

Indexed as

AnimalsAntimicrobial Cationic PeptidesCathelicidinsColonEpithelial CellsHomeostasisIntestinal MucosaMacrophagesMiceMice, KnockoutAntimicrobial Cationic PeptidesCathelicidinsbacteriaCampCnlpcolonCRAMPepithelial cell-derived CRAMPinflammationmucosamyeloid cell-derived CRAMPnecrosisproliferation

Identifiers

PMID33104252
PMCPMC7898386
OpenAlexW3094626983

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.