Evidence map›Paper›PMID 33103591›Full record

ArticleTherapeutic advances in respiratory disease

Current situation of asthma-COPD overlap in Chinese patients older than 40 years with airflow limitation: a multicenter, cross-sectional, non-interventional study.

Jian Kang, Jinping Zheng, Baiqiang Cai, Fuqiang Wen, Wanzhen Yao, Xiaoju Zhang, Yan Chen, Guansong Wang, Wen Li, Jie Cao

Registry-linked trialOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Therapeutic advances in respiratory disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02600221 (A Non-interventional Study to Investigate the Current Situation of Asthma-COPD Overlap Syndrome in Patients Over Age 40 With Persistent Airflow Limitation in China), which is not on this map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02600221 completednot on this map

A Non-interventional Study to Investigate the Current Situation of Asthma-COPD Overlap Syndrome in Patients Over Age 40 With Persistent Airflow Limitation in China

TypeobservationalSponsorAstraZenecaRan2015 to 2016Enrolled2,016ConditionsAsthma-COPD Overlap Syndrome
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it, 6 citations in OpenAlex.

  1. Clinical Indicators for Asthma-COPD Overlap: A Systematic Review and Meta-Analysis.International journal of chronic obstructive pulmonary disease · 2022
    Pooled it
  2. Article
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 10 institutions in 1 country.

Jian KangDepartment of Respiratory Medicine, The First Hospital of China Medical University, Shenyang, 110001, China.ORCID 0000-0001-6509-048X
Jinping ZhengState Key Laboratory of Respiratory Disease, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
Baiqiang CaiDepartment of Respiratory Medicine, Peking Union Medical College Hospital, Beijing, China.
Fuqiang WenDepartment of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, China.
Wanzhen YaoDepartment of Respiratory and Critical Care Medicine, Peking University Third Hospital, Beijing, China.
Xiaoju ZhangDepartment of Respiratory Medicine, Henan Provincial People's Hospital, Zhengzhou, China.
Yan ChenDepartment of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, China.
Guansong WangDepartment of Respiratory Medicine, Xinqiao Hospital of Third Military Medical University, Chongqing, China.
Wen LiDepartment of Respiratory Medicine, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.
Jie CaoDepartment of Respiratory Medicine, The General Hospital of Tianjin Medical University, Tianjin, China.
Army Medical University · CNCentral South University · CNChinese Academy of Medical Sciences & Peking Union Medical College · CNFirst Affiliated Hospital of Guangzhou Medical University · CNFirst Hospital of China Medical University · CNHenan Provincial People's Hospital · CNPeking University · CNSecond Affiliated Hospital of Zhejiang University · CNSichuan University · CNTianjin Medical University General Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsAsthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) is poorly recognized in China. Our study determined the distribution of ACO and its clinical characteristics among patients (aged ⩾40 years) with airflow limitation at Chinese tertiary hospitals.

methodsThis cross-sectional, non-interventional study (NCT02600221), conducted between December 2015 and October 2016 in 20 Tier-3 Chinese hospitals, included patients aged ⩾40 years with post-bronchodilator (BD) FEV

resultsIn 2003 patients (mean age 62.30 ± 9.86 years), distribution of ACO, COPD and asthma were 37.40%, 48.50% and 14.10%, respectively. Proportions of patients with A, B, C and D grouping were 11.70%, 31.00%, 6.90% and 50.30% as per GOLD 2017, whereas they were 15.10%, 51.10%, 3.60% and 30.20% as per GOLD 2015. Similar clinical symptoms were reported in all three groups. A higher percentage of ACO patients presented with dyspnea, wheezing and chest tightness. Compared with the COPD group, a greater proportion of ACO patients reported wheezing (74.6% and 65.40%), while a lower proportion in the ACO group reported cough (79.40%

conclusionDespite ACO affecting two-fifths of the study population, the initial diagnosis rate was low at 6% in China, thus warranting concerted efforts to improve ACO diagnosis. CLINICALTRIALS.GOV: [ClinicalTrials.gov identifier: NCT02600221] registered 22 October 2015, https://clinicaltrials.gov/ct2/show/NCT02600221

Indexed as

Respiratory Function TestsSymptom AssessmentAdultAgedAged, 80 and overAge DistributionAge FactorsAsthma-Chronic Obstructive Pulmonary Disease Overlap SyndromeChinaCross-Sectional StudiesFemaleForced Expiratory VolumeHumansLungMaleMiddle Agedasthmaasthma–COPD overlapCOPDdiagnosisdistribution

Identifiers

PMID33103591
PMCPMC7798366
OpenAlexW3094428083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.