ArticleThe Journal of international medical research2020
Primary intramedullary malignant melanoma: can imaging lead to the correct diagnosis?
Article in The Journal of international medical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- GNAQ mutation in primary spinal melanoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Atypical intramedullary spinal cord melanocytic neoplasm with hemorrhagic features in a child: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Neurosarcoidosis with spinal cord involvement manifested as the "flip-flop sign" on magnetic resonance imaging.Journal of neurology · 2025Article
- Intramedullary primary spinal cord melanoma: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Primary spinal meningeal melanoma with intramedullary and intradural extramedullary components-a case report.BJR case reports · 2025Article
- Primary spinal melanoma with special imaging appearances and pathologic characteristics: surgical treatment for two cases in a single center.Acta neurologica Belgica · 2024Article
- Primary cervicothoracic melanoma of spinal cord: a case report and literature review.Frontiers in oncology · 2024Article
- Article
- Primary spinal melanoma: illustrative case.Journal of neurosurgery. Case lessons · 2021Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanoma is a malignant neoplasm of melanin-producing cells. Melanoma usually occurs in the skin, but can also arise in any anatomical site that contains melanocytes, such as mucous membranes, the eyes, and the central nervous system (CNS). Primary CNS malignant melanoma most often develops in the leptomeninges. We report a case of a rare intramedullary melanoma of the thoracic spinal cord. A 78-year-old man was treated with surgery, radiotherapy, and immunotherapy for leptomeningeal spread. We also discuss the role of imaging methods in diagnosis and follow-up. Medullary melanoma occurs more frequently in adults. The most common presenting symptoms are the insidious onset of lower extremity weakness and paresthesia. Magnetic resonance imaging is the method of choice for evaluation. Although there are no imaging features to accurately distinguish primary malignant melanoma from other melanocytic or hemorrhagic tumors, hyperintensity on T1-weighted magnetic resonance imaging should lead to inclusion of this neoplasm in differential diagnosis of spinal cord tumors. Positron emission tomography-computed tomography is a useful auxiliary examination to evaluate the extent of local and metastatic disease. Surgical resection is the primary treatment for intramedullary melanoma. However, the efficacy of adjunctive radiotherapy and chemotherapy for primary spinal cord malignant melanoma is still controversial.
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