Evidence map›Paper›PMID 33103560›Full record

ArticleJournal of psychopharmacology (Oxford, England)2020

Dissociable contributions of mediodorsal and anterior thalamic nuclei in visual attentional performance: A comparison using nicotinic and muscarinic cholinergic receptor antagonists.

Craig P Mantanona, Tadej Božič, Yogita Chudasama, Trevor W Robbins, Jeffrey W Dalley, Johan Alsiö, Ilse S Pienaar

Open access · hybridAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
  3. Estrus cycle-dependent working memory effects of prefrontal cortex corticotropin-releasing factor neurotransmission.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Craig P MantanonaFaculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, UK.
Tadej BožičDepartment of Psychology, University of Cambridge, Cambridge, UK.
Yogita ChudasamaSection on Behavioral Neuroscience, National Institute of Mental Health, Bethesda, USA.
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Cambridge, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Cambridge, UK.
Johan AlsiöDepartment of Psychology, University of Cambridge, Cambridge, UK.
Ilse S PienaarSchool of Life Sciences, University of Sussex, Brighton, UK.ORCID 0000-0001-6507-9563
University of Cambridge · GBNational Institute of Mental Health · USNorthumbria University · GBUniversity of Sussex · GB

Funding

Neural Circuits Underlying the Control of Executive and Emotional BehaviorZIAMH002951 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI CHUDASAMA, YOGITA · 2016 to 2025
$17.5M
Intramural NIH HHS ZIA MH002951
6 · The paper itself

Abstract

backgroundThalamic subregions mediate various cognitive functions, including attention, inhibitory response control and decision making. Such neuronal activity is modulated by cholinergic thalamic afferents and deterioration of such modulatory signaling has been theorised to contribute to cognitive decline in neurodegenerative disorders. However, the thalamic subnuclei and cholinergic receptors involved in cognitive functioning remain largely unknown.

aimsWe investigated whether muscarinic or nicotinic receptors in the mediodorsal thalamus and anterior thalamus contribute to rats' performance in the five-choice serial reaction time task, which measures sustained visual attention and impulsive action.

methodsMale Long-Evans rats were trained in the five-choice serial reaction time task then surgically implanted with guide cannulae targeting either the mediodorsal thalamus or anterior thalamus. Reversible inactivation of either the mediodorsal thalamus or anterior thalamus were achieved with infusions of the γ-aminobutyric acid-ergic agonists muscimol and baclofen prior to behavioural assessment. To investigate cholinergic mechanisms, we also assessed the behavioural effects of locally administered nicotinic (mecamylamine) and muscarinic (scopolamine) receptor antagonists.

resultsReversible inactivation of the mediodorsal thalamus severely impaired discriminative accuracy and response speed and increased omissions. Inactivation of the anterior thalamus produced less profound effects, with impaired accuracy at the highest dose. In contrast, blocking cholinergic transmission in these regions did not significantly affect five-choice serial reaction time task performance. CONCLUSIONS/INTERPRETATIONS: These findings show the mediodorsal thalamus plays a key role in visuospatial attentional performance that is independent of local cholinergic neurotransmission.

Indexed as

AnimalsAnterior Thalamic NucleiAttentionBehavior, AnimalGABA AgonistsImpulsive BehaviorMaleMediodorsal Thalamic NucleusMuscarinic AntagonistsNicotinic AntagonistsPsychomotor PerformanceRatsRats, Long-EvansReceptors, MuscarinicReceptors, NicotinicSpace PerceptionGABA AgonistsMuscarinic AntagonistsNicotinic AntagonistsReceptors, MuscarinicReceptors, NicotinicAcetylcholineattentionmuscarinic receptorsnicotinic receptorsprefrontal cortexthalamus

Identifiers

PMID33103560
PMCPMC7708668
OpenAlexW3093541699

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.