Evidence map›Paper›PMID 33103515›Full record

ArticleInternational journal of immunopathology and pharmacology

Frequency of CD4+ regulatory T cells, CD8+ T cells, and human papilloma virus infection in Egyptian Women with breast cancer.

Amany M Tawfeik, Ahmed Mora, Ahmed Osman, Manar M Moneer, Nabila El-Sheikh, Mohamed Elrefaei

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Article in International journal of immunopathology and pharmacology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amany M TawfeikMolecular Immunology Unit for Infectious Diseases, Department of Microbiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Ahmed MoraDepartment of Chemistry, Faculty of Science, Al-Azhar University, Cairo, Egypt.
Ahmed OsmanDepartment of Biochemistry, Faculty of Science, Ain Shams University, Cairo, Egypt.
Manar M MoneerDepartment of Epidemiology and Statistics, National Cancer Institute, Cairo University, Cairo, Egypt.
Nabila El-SheikhMolecular Immunology Unit for Infectious Diseases, Department of Microbiology, Faculty of Medicine for Girls, Al-Azhar University, Cairo, Egypt.
Mohamed ElrefaeiDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Jacksonville, FL, USA.ORCID https://orcid.org/0000-0002-2030-4779

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several subsets of regulatory CD4+ T cells (CD4+ Tregs) have been described in peripheral blood and tumor microenvironment of breast cancer (BC) patients and may play a role in the progression of BC. High-risk human papilloma virus (HR-HPV) has a causal role in cervical, head, and neck tumors but the role of HR-HPV in evoking neoplasia in BC is still unclear. In this study we assessed the prevalence of CD4+CD25+ FOXP3+ regulatory T cells (CD4+Tregs) and CD3+ CD8+ T cells by flow cytometry in peripheral blood from a total of 55 Egyptian women, including 20 treatment-naïve BC, 15 with breast benign lesions (BBL), and 20 healthy volunteers (HV). HR-HPV genotypes type 16, 18, and 31 were investigated in breast tissue from all BC and BBL patients using Real-Time PCR. HR-HPV was detected in 4/20 (20%) and 0/15 (0%) BC and BBL patients respectively. The frequency of CD4+ Tregs was significantly higher in BC compared to BBL and HV, (

Indexed as

AdultAgedBreast NeoplasmsCase-Control StudiesCD8-Positive T-LymphocytesEgyptFemaleFlow CytometryHumansImmunophenotypingMiddle AgedPapillomavirus InfectionsPhenotypePrognosisT-Lymphocytes, Regulatorybreast cancerHPVTreg

Identifiers

PMID33103515
PMCPMC7786412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.