Evidence map›Paper›PMID 33103446›Full record

ArticleAmerican journal of physiology. Renal physiology2020

Renal lymphatic vessel dynamics.

Elaine L Shelton, Hai-Chun Yang, Jianyong Zhong, Michele M Salzman, Valentina Kon

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.2field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Article
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  6. Review
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  9. Article
  10. Review
  11. The lymphatics in kidney health and disease.Nature reviews. Nephrology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Elaine L SheltonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.ORCID 0000-0003-0929-2882
Hai-Chun YangDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Jianyong ZhongDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Michele M SalzmanDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Valentina KonDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee.
Vanderbilt University · USVanderbilt University Medical Center · US

Funding

Non-coding RNA & Bioinformatics CoreP01HL116263 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI LINTON, MACRAE F · 2014 to 2025
$24.7M
HHS | National Institutes of Health (NIH) 1P01HL116263NHLBI NIH HHS P01 HL116263
6 · The paper itself

Abstract

Similar to other organs, renal lymphatics remove excess fluid, solutes, and macromolecules from the renal interstitium. Given the kidney's unique role in maintaining body fluid homeostasis, renal lymphatics may be critical in this process. However, little is known regarding the pathways involved in renal lymphatic vessel function, and there are no studies on the effects of drugs targeting impaired interstitial clearance, such as diuretics. Using pressure myography, we showed that renal lymphatic collecting vessels are sensitive to changes in transmural pressure and have an optimal range of effective pumping. In addition, they are responsive to vasoactive factors known to regulate tone in other lymphatic vessels including prostaglandin E

Indexed as

AnimalsCalciumChloridesFurosemideKidneyLymphatic VesselsMaleNG-Nitroarginine Methyl EsterNitric OxidePressureRatsRats, Sprague-DawleySodium Potassium Chloride Symporter InhibitorsCalciumChloridesFurosemideNG-Nitroarginine Methyl EsterNitric OxideSodium Potassium Chloride Symporter Inhibitorsfurosemideloop diureticspressure myographyrenal lymphatics

Identifiers

PMID33103446
PMCPMC7792696
OpenAlexW3093622366

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.