ArticleClinical and experimental dental research2021
Cytotoxicity evaluation of dental and orthodontic light-cured composite resins.
Article in Clinical and experimental dental research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed.
- Hydrophobic monomer systems for dental composites: development and physicochemical evaluation of UDMA/IBOMA formulations.BMC oral health · 2026Article
- Anti-biofilm, anti-quorum sensing potential, cytotoxicity, and UPLC-UV/DAD-MS/MS/QTOF profiling of Prosopis Africana (Guill. & Perr.) Taub. leaves and stems extracts: benefits of a traditional medicine in dental care.BMC complementary medicine and therapies · 2025Article
- Eugenol Nanoparticles in Dental Composites: Literature Review of Antimicrobial, Anti-Inflammatory, and Clinical Applications.Microorganisms · 2025Review
- Bisphenol A Release from Fiber-Reinforced vs. Conventional Stainless-Steel Fixed Retainers: An In Vitro Study.Journal of functional biomaterials · 2025Article
- Article
- The Impact of Adding Chitosan Nanoparticles on Biofilm Formation, Cytotoxicity, and Certain Physical and Mechanical Aspects of Directly Printed Orthodontic Clear Aligners.Nanomaterials (Basel, Switzerland) · 2023Article
- In vitro cytotoxicity of resin cement and its influence on the expression of antioxidant genes.Acta odontologica latinoamericana : AOL · 2023Article
- Histocompatibility of Light-Curing Composites Used in Pediatric Dentistry in Human Oral Fibroblast Cells.Journal of dentistry (Shiraz, Iran) · 2023Article
- Cytotoxicity and reactive oxygen species production induced by different co-monomer eluted from nanohybrid dental composites.BMC oral health · 2023Article
- Release of leachable products from resinous compounds in the saliva of children with anterior open bite treated with spur.Journal of applied oral science : revista FOB · 2023Article
- Alkyl trimethyl ammonium bromide for the formulation of antibacterial orthodontic resins.Clinical oral investigations · 2022Article
- Comparative In Vitro Biocompatibility Study of the Two Orthodontic Bonding Materials of Different Types.Polymers · 2022Article
- 3-Year Clinical Performance of a New Pit and Fissure Sealant.Journal of clinical medicine · 2022Article
- Evaluation of residual monomer release after polymerization of different restorative materials used in pediatric dentistry.BMC oral health · 2022Article
- Monomer Release from Dental Resins: The Current Status on Study Setup, Detection and Quantification for In Vitro Testing.Polymers · 2022Review
- Fabrication and characterization of low-shrinkage dental composites containing montmorillonite nanoclay.Odontology · 2022Article
- Physical/Mechanical and Antibacterial Properties of Orthodontic Adhesives Containing Calcium Phosphate and Nisin.Journal of functional biomaterials · 2021Article
- A Review on Current Trends of Polymers in Orthodontics: BPA-Free and Smart Materials.Polymers · 2021Review
- Cytotoxicity evaluation of dental and orthodontic light-cured composite resins.Clinical and experimental dental research · 2021Article
- Biological effects of two nano-composite resins on human gingival fibroblast (anJournal of oral biology and craniofacial researchArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionThe aim of this study was to determine the cytotoxicity of light-cured composite resins (Clearfil ES-2, Clearfil ES Flow, Filtek Supreme XTE, Grengloo, Blugloo, Transbond XT, and Transbond LR) then to assess leachable components in contact with human gingival fibroblasts (GFs) and to quantity detected bisphenol A (BPA).
methodsLight-cured composite resin discs were immersed for 24 hours in gingival fibroblastic medium (n = 3 for each product) and in control medium (n = 2 for each product) contained in plate. Cytotoxicity of the products (n = 95) was determined by the measure of cell viability using MTT assay after reading the optical densities of the plates. The analysis of leachable components was done by gas phase chromatography and mass spectrometry (GC-MS) and detected BPA was quantified. The limit of quantification was 0.01 μg/mL. Statistical analyses were performed by using IBM SPSS Statistics 20 and Kruskal-Wallis and Mann-Whitney U-tests were applied.
resultsCell viabilities were between 85 and 90%. Many chemical compounds including triethylene glycol dimethacrylate (TEGDMA) and BPA were identified. The average concentrations were 0.67 μg/mL ± 0.84 in the control medium and 0.73 μg/mL ± 1.05 in the fibroblastic medium. Filtek Supreme XTE presented the highest concentration of BPA with 2.16 μg/mL ± 0.65 and Clearfil ES Flow presented the lowest with 0.25 μg/mL ± 0.35. No BPA was detected with Transbond XT and Transbond LR. Clearfil ES Flow, Filtek Supreme XTE, Grengloo and Transbond LR presented residual TEGDMA.
conclusionsLight-cured composite resins are slightly cytotoxic opposite GFs and release many components including BPA and TEGDMA. Clinical precautions should be taken to decrease the release of these monomers.
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