Evidence map›Paper›PMID 33103374›Full record

ArticleStem cells translational medicine2021

Window of opportunity for human amnion epithelial stem cells to attenuate astrogliosis after umbilical cord occlusion in preterm fetal sheep.

Joanne O Davidson, Lotte G van den Heuij, Mhoyra Fraser, Guido Wassink, Suzanne L Miller, Rebecca Lim, Euan M Wallace, Graham Jenkin, Alistair J Gunn, Laura Bennet

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Joanne O DavidsonFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Lotte G van den HeuijFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Mhoyra FraserFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Guido WassinkFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
Suzanne L MillerThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.ORCID 0000-0002-0451-8304
Rebecca LimThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Euan M WallaceThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Graham JenkinThe Ritchie Centre, Hudson Institute of Medical Research, Clayton, Victoria, Australia.
Alistair J GunnFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.ORCID 0000-0003-0656-7035
Laura BennetFetal Physiology and Neuroscience Group, Department of Physiology, The University of Auckland, Auckland, New Zealand.
University of Auckland · NZHudson Institute of Medical Research · AUMonash University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is increasing evidence that administration of many types of stem cells, including human amnion epithelial cells (hAECs), can reduce hypoxic-ischemic injury, including in the perinatal brain. However, the therapeutic window for single dose treatment is not known. We compared the effects of early and delayed intracerebroventricular administration of hAECs in fetal sheep at 0.7 gestation on brain injury induced by 25 minutes of complete umbilical cord occlusion (UCO) or sham occlusion. Fetuses received either 1 × 10

Indexed as

AmnionGliosisStem Cell TransplantationAnimalsEpithelial CellsFemaleFetusHumansHypoxia, BrainPregnancySheepStem CellsUmbilical Cordasphyxiainflammationneuroprotectionpreterm birthstem cells

Identifiers

PMID33103374
PMCPMC7900589
OpenAlexW3094527147

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.