Evidence map›Paper›PMID 33103129›Full record

ArticleCell reports. Medicine2020

Unacylated-Ghrelin Impairs Hippocampal Neurogenesis and Memory in Mice and Is Altered in Parkinson's Dementia in Humans.

Amanda K E Hornsby, Luke Buntwal, Maria Carla Carisi, Vanessa V Santos, Fionnuala Johnston, Luke D Roberts, Martina Sassi, Mathieu Mequinion, Romana Stark, Alex Reichenbach and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 37 citations in OpenAlex.

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  18. Discovery of a dual-action small molecule that improves neuropathological features of Alzheimer's disease mice.Proceedings of the National Academy of Sciences of the United States of America · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 5 institutions in 2 countries.

Amanda K E HornsbyMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Luke BuntwalMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Maria Carla CarisiMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Vanessa V SantosBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
Fionnuala JohnstonFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Luke D RobertsMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Martina SassiMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Mathieu MequinionBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
Romana StarkBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
Alex ReichenbachBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
Sarah H LockieBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
Mario SiervoFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Owain HowellMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Alwena H MorganMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Timothy WellsSchool of Biosciences, Cardiff University, Cardiff, UK.
Zane B AndrewsBiomedical Discovery Institute, Department of Physiology, Monash University, Clayton, VIC, Australia.
David J BurnFaculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK.
Jeffrey S DaviesMolecular Neurobiology, Institute of Life Sciences, School of Medicine, Swansea University, Swansea, UK.
Swansea University · GBAustralian Regenerative Medicine Institute · AUMonash University · AUNewcastle University · GBCardiff University · GB

Funding

Medical Research Council G0902250
6 · The paper itself

Abstract

Blood-borne factors regulate adult hippocampal neurogenesis and cognition in mammals. We report that elevating circulating unacylated-ghrelin (UAG), using both pharmacological and genetic methods, reduced hippocampal neurogenesis and plasticity in mice. Spatial memory impairments observed in ghrelin-O-acyl transferase-null (GOAT

Indexed as

AcyltransferasesAnimalsBrain-Derived Neurotrophic FactorCognitionDisease Models, AnimalFemaleGene Expression RegulationGhrelinHippocampusHumansMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutNeurogenesisacyl-ghrelinAcyltransferasesBdnf protein, mouseBrain-Derived Neurotrophic FactorGhrelinMBOAT4 protein, humanMboat4 protein, mouseMembrane Proteinsacyl-ghrelinadult hippocampal neurogenesisAG:UAGBDNFbiomarkerghrelinGOATmemoryParkinson disease dementiaunacylated-ghrelin

Identifiers

PMID33103129
PMCPMC7575905
OpenAlexW3094417216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.