Evidence map›Paper›PMID 33103056›Full record

ArticleEpigenetics insights2020

DNA Methylation of Endoglin Pathway Genes in Pregnant Women With and Without Preeclampsia.

Allison H Rietze, Yvette P Conley, Dianxu Ren, Cindy M Anderson, James M Roberts, Arun Jeyabalan, Carl A Hubel, Mandy J Schmella

Open access · bronzeAbstract read
In one paragraph

Article in Epigenetics insights, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Trophoblast Fusion in Hypertensive Disorders of Pregnancy and Preeclampsia.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Allison H RietzeDepartment of Health Promotion and Development (School of Nursing), University of Pittsburgh, Pittsburgh, PA, USA.
Yvette P ConleyDepartment of Health Promotion and Development (School of Nursing), University of Pittsburgh, Pittsburgh, PA, USA.
Dianxu RenDepartment of Health and Community Systems (School of Nursing), University of Pittsburgh, Pittsburgh, PA, USA.
Cindy M AndersonMartha S Pitzer Center for Women, Children, and Youth (College of Nursing), The Ohio State University, Columbus, OH, USA.
James M RobertsDepartment of Obstetrics, Gynecology, & Reproductive Sciences (School of Medicine), University of Pittsburgh, PA, USA.
Arun JeyabalanDepartment of Obstetrics, Gynecology, & Reproductive Sciences (School of Medicine), University of Pittsburgh, PA, USA.
Carl A HubelDepartment of Obstetrics, Gynecology, & Reproductive Sciences (School of Medicine), University of Pittsburgh, PA, USA.
Mandy J SchmellaDepartment of Health Promotion and Development (School of Nursing), University of Pittsburgh, Pittsburgh, PA, USA.
University of Pittsburgh · USMagee-Womens Research Institute · USColumbus Center · US

Funding

TROPHOBLAST PRODUCTS IN GENESIS OF PREECLAMPSIAP01HD030367 · NICHD · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI HUBEL, CARL A · 1993 to 2012
$17.2M
Targeting Research and Academic Training of Nurses in GenomicsT32NR009759 · NINR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CONLEY, YVETTE P · 2006 to 2025
$4.5M
Mechanisms Modulating the Association between the ENG Pathway and PreeclampsiaF32NR014622 · NINR · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI SCHMELLA, MANDY JO · 2013 to 2014
$97k
NICHD NIH HHS P01 HD030367NINR NIH HHS F32 NR014622NINR NIH HHS T32 NR009759
6 · The paper itself

Abstract

objectiveWe compared blood-based DNA methylation levels of endoglin (

methodsWe used EpiTect Methyl II PCR Assays to evaluate DNA methylation of CpG islands located in promoter regions of

resultsThe majority of the preeclampsia cases delivered at ⩾34 weeks' gestation (83%). Average methylation levels for

conclusionAdditional epigenetic studies that include larger sample sizes, investigate preeclampsia subtypes, and capture methylation status of CpG island shores and shelves are needed to further inform us of the potential role that

Indexed as

Methylationpre-eclampsiapregnancy

Identifiers

PMID33103056
PMCPMC7550939
OpenAlexW3091857845

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.