Evidence map›Paper›PMID 33102973›Full record

ArticleKidney international reports2020

Validity of Urine NGALds Dipstick for Acute Kidney Injury in a Malawian Trauma Cohort.

Erica C Bjornstad, William Muronya, Manly Kamija, Zachary Smith, Charles K Munthali, Keisha Gibson, Amy K Mottl, Anthony Charles, Stephen W Marshall, Yvonne M Golightly and 1 more

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Erica C BjornstadDepartment of Pediatrics, Division of Nephrology, University of Alabama Birmingham, Alabama, USA.
William MuronyaDepartment of Surgery, Kamuzu Central Hospital, Lilongwe, Malawi.
Manly KamijaUniveristy of North Carolina Project Malawi, Lilongwe, Malawi.
Zachary SmithUniveristy of North Carolina Project Malawi, Lilongwe, Malawi.
Charles K MunthaliDepartment of Medicine, Renal Unit, Kamuzu Central Hospital, Lilongwe, Malawi.
Keisha GibsonDepartment of Medicine, Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Amy K MottlDepartment of Medicine, Division of Nephrology and Hypertension, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Anthony CharlesDepartment of Surgery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Stephen W MarshallDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Public Health, Chapel Hill, North Carolina, USA.
Yvonne M GolightlyDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Public Health, Chapel Hill, North Carolina, USA.
Emily W GowerDepartment of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Public Health, Chapel Hill, North Carolina, USA.
University of North Carolina at Chapel Hill · USKamuzu Central Hospital · MWStanford University · USUniversity of Alabama · US

Funding

UJMT – ORWH – Gazzetta, Issa-BoubeD43TW009340 · FIC · UNIV OF NORTH CAROLINA CHAPEL HILL · PI William Checkley, Benjamin H. Chi · 2017 to 2026
$14.8M
RENAL EPIDEMIOLOGY TRAINING PROGRAMT32DK007750 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI FALK, RONALD J · 1999 to 2022
$5.5M
FIC NIH HHS D43 TW009340NIDDK NIH HHS T32 DK007750
6 · The paper itself

Abstract

introductionAcute kidney injury (AKI) is a major cause of mortality worldwide, particularly in low-resource settings with limited diagnostic testing. Neutrophil gelatinase-associated lipocalin (NGAL) has shown promise in predicting AKI. Nested within a larger, prospective cohort study evaluating AKI incidence in admitted trauma patients, our objective was to evaluate a novel dipstick, NGALds, for the prediction of AKI in Malawi, Africa.

methodsParticipants were >6 months of age. Spearman rank correlation coefficients (

resultsWe enrolled 285 participants (one-third children). Thirteen percent developed AKI. The dipstick captured 45 of 52 participants (86.5%) with moderate- or high-risk NGAL values on laboratory-based testing (

conclusionsThe NGALds dipstick performed similarly to the NGAL Test in this low-resource setting and may be a useful tool to rule out AKI. It may be even more important in predicting high mortality risk among children.

Indexed as

acute kidney injuryAfricaNGALpoint-of-care

Identifiers

PMID33102973
PMCPMC7569698
OpenAlexW3044410654

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.