Evidence map›Paper›PMID 33102968›Full record

ArticleKidney international reports2020

External Validation of International Risk-Prediction Models of IgA Nephropathy in an Asian-Caucasian Cohort.

Yuemiao Zhang, Ling Guo, Zi Wang, Jinwei Wang, Lee Er, Sean J Barbour, Hernan Trimarchi, Jicheng Lv, Hong Zhang

Erratum issuedAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Incorporating Pathomics Into IgAN Risk Prediction.Kidney international reports · 2026
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  6. Article
  7. Review
  8. Article
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  10. Review
  11. Article
  12. Contemporary review of IgA nephropathy.Frontiers in immunology · 2024
    Review
  13. Article
  14. Review
  15. Review
  16. Validation of two IgA nephropathy risk-prediction tools using a cohort with a long follow-up.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Article
  17. Machine learning in predictingFrontiers in immunology · 2023
    Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yuemiao ZhangRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.
Ling GuoRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.
Zi WangRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.
Jinwei WangRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.
Lee ErBC Renal, Vancouver, British Columbia, Canada.
Sean J BarbourBC Renal, Vancouver, British Columbia, Canada.
Hernan TrimarchiNephrology Service, Hospital Británico de Buenos Aires, Argentina.
Jicheng LvRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.
Hong ZhangRenal Division, Department of Medicine, Peking University First Hospital, Beijing China; Institute of Nephrology, Peking University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTwo prediction models for IgA nephropathy (IgAN) using clinical variables and the Oxford MEST scores were developed and validated in 2 multiethnic cohorts. Additional external validation is required.

methodsBiopsy-proven Chinese and Argentinian patients with IgAN were included. The primary outcome was defined as a 50% decline in estimated glomerular filtration rate (eGFR) or end-stage renal disease. C-statistics and stratified analyses were used for model discrimination, coefficient of determination (R

resultsA total of 1275 patients were enrolled, with a mean age of 34 (interquartile range: 27-42) years, 50% of whom (638 of 1275) were men. Use of renin-angiotensin system blockers was higher than in previously reported cohorts, whereas other variables were comparable. The C-statistic of the models was 0.81, and R

conclusionThe prediction models showed good performance on personalized risk assessment, which may be used as drug-specific, precision-medicine approaches to treatment decisionmaking.

Indexed as

calibrationdiscriminationexternal validationIgA nephropathyprediction models

Identifiers

PMID33102968
PMCPMC7572322

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.