ArticleBioactive materials2021
3D additive manufactured composite scaffolds with antibiotic-loaded lamellar fillers for bone infection prevention and tissue regeneration.
Article in Bioactive materials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- A near-infrared regulated programmable multi-mode periosteum scaffold for sequential healing of infected bone defects.Bioactive materials · 2026Article
- Multifunctional polyoxomolybdate cluster loaded into hydrogel for augmented bone regeneration through synergistic immunomodulation and osteogenesis.Bioactive materials · 2026Article
- Alveolar Bone Regeneration: Smart Biomaterials and Physical Stimulation.Journal of biomedical materials research. Part B, Applied biomaterials · 2026Review
- Multi-Objective Optimization of Mechanical and Geometric Properties of 3D-Printed PLA Porous Scaffolds for Biomedical Applications.Materials (Basel, Switzerland) · 2026Article
- Review
- Advances in 3D-Printed Drug Delivery and Screening Platforms for Bone Disease Therapy.Pharmaceutics · 2025Review
- Melt-Extrusion Additive Manufacturing for Tissue Engineering: Applications and Limitations.3D printing and additive manufacturing · 2025Article
- Two-dimensional nanomaterials for bone disease therapy: multifunctional platforms for regeneration, anti-infection and tumor ablation.Journal of nanobiotechnology · 2025Review
- Global Advancements in Bioactive Material Manufacturing for Drug Delivery: A Comprehensive Study.ACS omega · 2025Article
- Biomaterials for bone infections: antibacterial mechanisms and immunomodulatory effects.Frontiers in cellular and infection microbiology · 2025Review
- Real-time imaging of dynamic tissues.Nature methods · 2023Article
- Layered Double Hydroxides: A Novel Promising 2D Nanomaterial for Bone Diseases Treatment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Review
- Triple-functional bone adhesive with enhanced internal fixation, bacteriostasis and osteoinductive properties for open fracture repair.Bioactive materials · 2023Article
- Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering.Pharmaceutics · 2023Review
- Bioceramic-based scaffolds with antibacterial function for bone tissue engineering: A review.Bioactive materials · 2022Review
- Chloroplast-inspired Scaffold for Infected Bone Defect Therapy: Towards Stable Photothermal Properties and Self-Defensive Functionality.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2022Article
- Smart Bacteria-Responsive Drug Delivery Systems in Medical Implants.Journal of functional biomaterials · 2022Review
- Biomaterials for Regenerative Medicine in Italy: Brief State of the Art of the Principal Research Centers.International journal of molecular sciences · 2022Review
- Vancomycin Containing PDLLA and PLGA/β-TCP Inhibit Biofilm Formation but Do Not Stimulate Osteogenic Transformation of Human Mesenchymal Stem Cells.Frontiers in surgery · 2022Article
- Additive Manufactured Scaffolds for Bone Tissue Engineering: Physical Characterization of Thermoplastic Composites with Functional Fillers.ACS applied polymer materials · 2021Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Bone infections following open bone fracture or implant surgery remain a challenge in the orthopedics field. In order to avoid high doses of systemic drug administration, optimized local antibiotic release from scaffolds is required. 3D additive manufactured (AM) scaffolds made with biodegradable polymers are ideal to support bone healing in non-union scenarios and can be given antimicrobial properties by the incorporation of antibiotics. In this study, ciprofloxacin and gentamicin intercalated in the interlamellar spaces of magnesium aluminum layered double hydroxides (MgAl) and α-zirconium phosphates (ZrP), respectively, are dispersed within a thermoplastic polymer by melt compounding and subsequently processed via high temperature melt extrusion AM (~190 °C) into 3D scaffolds. The inorganic fillers enable a sustained antibiotics release through the polymer matrix, controlled by antibiotics counterions exchange or pH conditions. Importantly, both antibiotics retain their functionality after the manufacturing process at high temperatures, as verified by their activity against both Gram + and Gram - bacterial strains. Moreover, scaffolds loaded with filler-antibiotic do not impair human mesenchymal stromal cells osteogenic differentiation, allowing matrix mineralization and the expression of relevant osteogenic markers. Overall, these results suggest the possibility of fabricating dual functionality 3D scaffolds via high temperature melt extrusion for bone regeneration and infection prevention.
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