ArticleJGH open : an open access journal of gastroenterology and hepatology2020
Hepatic osteodystrophy and fracture risk prediction using FRAX tool in Indian patients with cirrhosis.
Article in JGH open : an open access journal of gastroenterology and hepatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 8 citations in OpenAlex.
- Association between HBV DNA levels and bone mineral density in antiviral-naive chronic hepatitis B patients.Frontiers in endocrinology · 2026Article
- Osteoporosis and Fragility Fractures in Patients with Liver Cirrhosis: Usefulness of FRAXJournal of clinical medicine · 2023Article
- Clinical Usefulness of FRAX Score for Predicting Sarcopenia in Patients with Chronic Liver Disease.Journal of clinical medicine · 2021Article
- Investigation of the influential factors for hepatic osteodystrophy in chronic liver disease: A case-control survey among the patients attending a tertiary care hospital in a rural region of Northern India.Tzu chi medical journalArticle
- Long Term Complications of Immunosuppression Post Liver Transplant.Journal of clinical and experimental hepatologyArticle
- Caring for the Bone Health Among Liver Transplant Recipients.Journal of clinical and experimental hepatologyReview
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
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Abstract
BACKGROUND AND
aimThe main clinical relevance of hepatic osteodystrophy is the increased risk of fractures. Dual-energy X ray absorptiometry (DEXA)-based assessment of bone mineral density, the current gold standard for diagnosing osteoporosis, is not the sole determinant of fracture risk. Other clinical risk factors also play an important role. This study was carried out to assess the prevalence and risk factors of hepatic osteodystrophy and estimate the entailed fracture risk by using the FRAX tool in a cohort of Indian cirrhotics.
methodsConsecutive patients with cirrhosis (
resultsThe study cohort was predominantly male (86.7%) with a median age of 49 (40-65) years. Alcohol was the most common etiology (80%). All patients had Child-Turcotte-Pugh class B (63.3%) or class B (36.7%) cirrhosis. Hepatic osteodystrophy was present in 83.3% patients. On multivariate analysis, smoking (odds ratio [OR]: 3.1 [1.76-4.7],
conclusionHepatic osteodystrophy is widely prevalent among Indian patients with cirrhosis and entails a high risk of fractures. Approximately one-third of patients with cirrhosis need treatment to reduce the risk of osteoporotic fractures.
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