SynthesisFrontiers in medicine2020
Association of Peripheral Lymphocyte and the Subset Levels With the Progression and Mortality of COVID-19: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- Impact of SARS-CoV-2 Breakthrough Infection on Short-Term CD4 Count Among Adults With HIV in the United States From 2020 to 2022.Open forum infectious diseases · 2026Article
- Functionality of immune cells in COVID-19 infection: development of cell-based therapeutics.BioImpacts : BI · 2023Review
- Lymphocyte Subsets in Mild COVID-19 Pediatric Patients.Turkish archives of pediatrics · 2022Article
- Pathological effects of SARS-CoV-2 on hematological and immunological cells: Alterations in count, morphology, and function.Pathology, research and practice · 2022Review
- Multi-omic approach identifies a transcriptional network coupling innate immune response to proliferation in the blood of COVID-19 cancer patients.Cell death & disease · 2021Article
- Longitudinal trajectories of pneumonia lesions and lymphocyte counts associated with disease severity among convalescent COVID-19 patients: a group-based multi-trajectory analysis.BMC pulmonary medicine · 2021Article
- Multivariable mortality risk prediction using machine learning for COVID-19 patients at admission (AICOVID).Scientific reports · 2021Observational
- Cytokines and Leukocytes Subpopulations Profile in SARS-CoV-2 Patients Depending on the CT Score Severity.Viruses · 2021Article
- The Role of Immunogenetics in COVID-19.International journal of molecular sciences · 2021Review
- Dynamic changes in lymphocyte subsets and parallel cytokine levels in patients with severe and critical COVID-19.BMC infectious diseases · 2021Article
- Effects of Coronavirus Disease 2019 (COVID-19) on Peripheral Blood Lymphocytes and Their Subsets in Children: Imbalanced CD4Frontiers in pediatrics · 2021Article
- The predictive role of lymphocyte subsets and laboratory measurements in COVID-19 disease: a retrospective study.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current evidence is controversial in the association between peripheral lymphocyte levels and the progression and mortality of Corona Virus Disease 2019 (COVID-19), and this meta-analysis aimed to clarify the association. A systematic search was conducted in public databases to identify all relevant studies, and the study-specific odds ratio (OR) and 95% confidence intervals (CI) were pooled. Finally, 16 studies were identified with a total of 1,873 progressive COVID-19 cases and 5,177 stable COVID-19 cases. In COVID-19 progression, lymphocyte levels showed a significant negative correlation (OR: 0.68, 95% CI: 0.51-0.89), but it was not significant in the subsets of CD3+ T cells (OR: 0.97, 95% CI: 0.93-1.02), CD4+ T cells (OR: 0.93, 95% CI: 0.80-1.08), CD8+ T cells (OR: 0.96, 95% CI: 0.92-1.00), B cells (OR: 0.98, 95% CI: 0.92-1.04), or NK cells (OR: 0.80, 95% CI: 0.61-1.04). In COVID-19 mortality, lymphocyte levels showed a significant negative correlation (OR: 0.41, 95% CI: 0.20-0.85), but it was not significant in the subsets of CD3+ T cells (OR: 0.95, 95% CI: 0.86-1.05), CD4+ T cells (OR: 1.06, 95% CI: 0.86-1.31), CD8+ T cells (OR: 0.38, 95% CI: 0.14-1.01), B cells (OR: 0.98, 95% CI: 0.92-1.04), or NK cells (OR: 0.80, 95% CI: 0.61-1.04). In conclusion, current evidence suggests a significant negative association of peripheral lymphocyte levels with COVID-19 progression and mortality, but it was not significant in the subsets of CD3+ T cells, CD4+ T cells, CD8+ T cells, B cells, and NK cells.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.