Evidence map›Paper›PMID 33102255›Full record

ArticleFrontiers in cellular and infection microbiology2020

Cervical-Vaginal Microbiome and Associated Cytokine Profiles in a Prospective Study of HPV 16 Acquisition, Persistence, and Clearance.

Anna-Barbara Moscicki, Baochen Shi, Hazel Huang, Emma Barnard, Huiying Li

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Anna-Barbara MoscickiDivision of Adolescent and Young Adult Medicine, Department of Pediatrics, University of California, Los Angeles, Los Angeles, CA, United States.
Baochen ShiDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, CA, United States.
Hazel HuangDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, CA, United States.
Emma BarnardDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, CA, United States.
Huiying LiDepartment of Molecular and Medical Pharmacology, David Geffen School of Medicine, Crump Institute for Molecular Imaging, University of California, Los Angeles, Los Angeles, CA, United States.

Funding

Natural History of HPV Infection to NeoplasiaR37CA051323 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSCICKI, ANNA-BARBARA · 2005 to 2014
$15.4M
NCI NIH HHS R37 CA051323
6 · The paper itself

Abstract

Persistent human papillomavirus (HPV) infections is necessary for the development of cervical cancers. Consequently, understanding the biologic mechanisms resulting in clearance is key in cancer prevention. Similar to other mucosal sites, it is expected that the local microbiome plays a significant role in shaping the immune response responsible for HPV clearance. Using cervical wash repository samples from a prospective study of HPV in women, this study investigates the microbiome and its associated inflammatory milieu during HPV 16 pre-acquisition, persistence and clearance states. For comparison, samples from women with no history of HPV ever during the study period were selected. We showed that 9 of 13 inflammatory cytokines were found to be significantly increased in the immediate post-clearance visit compared to the pre-acquisition or infection visits.

Indexed as

Cervix UteriMicrobiotaCytokinesFemaleHuman papillomavirus 16HumansProspective StudiesCytokinescervixcytokineshuman papillomavirusinflammationmicrobiome

Identifiers

PMID33102255
PMCPMC7546785

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.