Evidence map›Paper›PMID 33102154›Full record

ArticleMethodsX2020

Development and validation of a RP-HPLC method for the simultaneous analysis of paracetamol, ibuprofen, olanzapine, and simvastatin during microalgae bioremediation.

Telma Encarnação, António Aguiar, Cátia Palito, Alberto A C C Pais, Maria G Campos, Abílio J F N Sobral, Hugh D Burrows

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MethodsX, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 24 citations in OpenAlex.

  1. Caffeine and 4-Hydroxybenzoic Acid Cocrystal Hydrate: Preparation, Characterization, and Evaluation.Chemphyschem : a European journal of chemical physics and physical chemistry · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Telma EncarnaçãoCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
António AguiarCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Cátia PalitoCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Alberto A C C PaisCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Maria G CamposCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Abílio J F N SobralCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
Hugh D BurrowsCQC, Department of Chemistry, University of Coimbra, 3004-535 Coimbra, Portugal.
University of Coimbra · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A rapid reverse phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the simultaneous quantification of paracetamol, ibuprofen, olanzapine, simvastatin and simvastatin acid in the context of microalgae bioremediation. The method was validated according to the guidelines of the US Food and Drug Administration (FDA), the International Conference on Harmonization (ICH), and Eurachem with respect to system suitability, linearity, accuracy, precision, recovery, limits of detection and quantification, ruggedness, selectivity and specificity. The estimated limits of detection and quantification were, respectively, 0.03 and 0.10 µg mL

Indexed as

BioremediationHPLCMethod validationMicroalgaePharmaceuticalsWastewater

Identifiers

PMID33102154
PMCPMC7569217
OpenAlexW3089115683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.