ArticlePhotoacoustics2020
A fiber optoacoustic emitter with controlled ultrasound frequency for cell membrane sonoporation at submillimeter spatial resolution.
Article in Photoacoustics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- All-optical generation and predictive modeling of focused pressure waves using Bessel beam shaping and a nanocomposite thin film.Photoacoustics · 2026Article
- Distinguishing Photoacoustic and Photothermal Neuron Stimulation Through Quantitative Mapping Spatiotemporal Field Evolution.bioRxiv : the preprint server for biology · 2026Article
- Miniaturized optically generated Bessel beam ultrasound for volumetric transcranial brain stimulation.Science advances · 2026Article
- Ultrafast subwavelength CVD-graphene nanoheater for the generation of broadband photoacoustic waves.Photoacoustics · 2026Article
- Modulating neuroplasticity for chronic pain relief: noninvasive neuromodulation as a promising approach.Experimental & molecular medicine · 2025Review
- Low frequency ultrasound elicits broad cortical responses inhibited by ketamine in mice.Communications engineering · 2024Article
- High-Precision Photoacoustic Neural Modulation Uses a Non-Thermal Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Photoacoustic: A Versatile Nongenetic Method for High-Precision Neuromodulation.Accounts of chemical research · 2024Review
- Force-Based Neuromodulation.Accounts of chemical research · 2024Review
- Multipoint Energy-Balanced Laser-Ultrasonic Transducer Based on a Thin-Cladding Fiber.Sensors (Basel, Switzerland) · 2024Article
- Intravital photoacoustic brain stimulation with high-precision.Journal of biomedical optics · 2024Review
- Ultrasonic photoacoustic emitter of graphene-nanocomposites film on a flexible substrate.Photoacoustics · 2022Article
- Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision.Light, science & applications · 2022Article
- A Microfluidic System of Gene Transfer by Ultrasound.Micromachines · 2022Article
- High-precision neural stimulation through optoacoustic emitters.Neurophotonics · 2022Article
- High-precision neural stimulation by a highly efficient candle soot fiber optoacoustic emitter.Frontiers in neuroscience · 2022Article
- Non-genetic photoacoustic stimulation of single neurons by a tapered fiber optoacoustic emitter.Light, science & applications · 2021Article
- Fiber endface photoacoustic generator for quantitative photoacoustic tomography.Optics letters · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Focused ultrasound has attracted great attention in minimally invasive therapeutic and mechanism studies. Frequency below 1 MHz is identified preferable for high-efficiency bio-modulation. However, the poor spatial confinement of several millimeters and large device diameter of ∼25 mm of typical sub-MHz ultrasound technology suffered from the diffraction limit, severely hindering its further applications. To address it, a fiber-based optoacoustic emitter (FOE) is developed, serving as a miniaturized ultrasound point source, with sub-millimeter confinement, composed of an optical diffusion layer and an expansion layer on an optical fiber. By modifying acoustic damping and light absorption performance, controllable frequencies in the range of 0.083 MHz-5.500 MHz are achieved and further induce cell membrane sonoporation with frequency dependent efficiency. By solving the problem of compromise between sub-MHz frequency and sub-millimeter precision via breaking the diffraction limit, the FOE shows a great potential in region-specific drug delivery, gene transfection and neurostimulation.
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Registered trials
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