Evidence map›Paper›PMID 33101894›Full record

ReviewJournal of oral biology and craniofacial research

Correlation of VEGF and MMP-2 levels in oral lichen planus: An in vivo immunohistochemical study.

Hala H Hazzaa, Marwa A M El Shiekh, Nora Abdelgawad, Ossama M Gouda, Naglaa M Kamal

Open access · greenAbstract readReview
In one paragraph

Review in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Hala H HazzaaDepartment of Oral Medicine, Periodontology, Diagnosis and Radiology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.
Marwa A M El ShiekhDepartment of Oral Biology, Faculty of Dental Medicine for Girls, Cairo, Egypt.
Nora AbdelgawadDepartment of Oral Medicine, Periodontology, Diagnosis and Radiology, Faculty of Dental Medicine for Girls, Al Azhar University, Cairo, Egypt.
Ossama M GoudaDepartment of Oral Medicine, Periodontology and Diagnosis, Faculty of Oral Medicine, Badr University, Cairo, Egypt.
Naglaa M KamalDepartment of Oral Pathology, Faculty of Oral and Dental Medicine, Ahram Canadian University, 6th of October City, Giza, Egypt.
Al-Azhar University · EGAhram Canadian University · EGBadr University in Cairo · EGGirls Incorporated · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThis study aimed to investigate the relation between vascular endothelial growth factors (VEGF) and matrix metalloproteinase-2 (MMP-2) in different oral lichen planus (OLP) forms compared to control patients.

methodsBiopsies from 60 patients were selected and equally distributed as follows: reticular/popular OLP (R/PLP), atrophic/erosive OLP (A/ELP) patients, healthy subjects (Control). All biopsies were immune-histochemical stained and statistically analyzed for VEGF and MMP-2 expression.

resultsImmune-expression of VEGF was significant between OLP and control (

conclusionMMP-2 and VEGF protein profiles support a role in the pathogenesis of OLP. Based the MMP-2 and VEGF findings in the A/ELP group, this pathway may have a role in the malignant transformation of these lesions. Both observations invite further study.

Indexed as

CarcinogenesisMatrix metalloproteinase-2Oral lichen planusPathogenesisVascular endothelial growth factor

Identifiers

PMID33101894
PMCPMC7578756
OpenAlexW3094432290

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.