ArticleJournal of oral biology and craniofacial research
Gestational protein restriction alters the RANKL/OPG system in the dental germ of offsprings.
Article in Journal of oral biology and craniofacial research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 4 citations in OpenAlex.
- Gestational Protein Restriction Promotes Osteoporotic Phenotype During Aging.Calcified tissue international · 2026Article
- Effects of gestational protein restriction on autophagy dynamics during odontogenesis.Cell and tissue research · 2026Article
- Mandible development under gestational protein restriction: cellular and molecular mechanisms.Journal of molecular histology · 2024Article
- Absence of melatonin during development impairs craniofacial and dental onset in rats.Clinical oral investigations · 2023Article
- Pulpal outcomes in orthodontic tooth movement in diabetes mellitus.Odontology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
Evaluate the dentinogenesis in the offspring of rats submitted to gestational protein restriction (GPR).
designThe offspring were evaluated at the 21st day of gestation (21 dG). Assessments were made of morphological parameters and the RANKL/OPG system - bone tissue maturation markers - in the upper incisor tooth germ. Pregnant 10-week-old female Wistar rats were divided into normal protein (NP, 17% casein, n = 5) and low protein (LP, 6% casein, n = 5) diet groups. At 21 dG, the offspring maxillae were collected for histomorphometric and immunohistochemical analyses.
resultsThe LP group showed decreased thickness of the dentin and odontoblast cell layers on the tooth germ. GPR led to decreased OPG expression and increased RANKL expression in the incisor germ.
conclusionThe results suggested that gestational protein restriction altered odontoblast RANKL/OPG expression and decreased dentin matrix deposition and thickness in tooth development.
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