Evidence map›Paper›PMID 33101701›Full record

ArticleMaternal health, neonatology and perinatology2020

Maternal and cord blood vitamin D level and the infant gut microbiota in a birth cohort study.

Zeinab Kassem, Alexandra Sitarik, Albert M Levin, Susan V Lynch, Suzanne Havstad, Kei Fujimura, Anita Kozyrskyj, Dennis R Ownby, Christine Cole Johnson, Germaine J M Yong and 2 more

Abstract read
In one paragraph

Article in Maternal health, neonatology and perinatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zeinab KassemDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Alexandra SitarikDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Albert M LevinDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Susan V LynchDepartment of Medicine, University of California, San Francisco, CA USA.
Suzanne HavstadDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Kei FujimuraDepartment of Medicine, University of California, San Francisco, CA USA.
Anita KozyrskyjDepartment of Pediatrics, University of Alberta, Alberta, Canada.
Dennis R OwnbyDivision of Allergy and Clinical Immunology, Department of Pediatrics, Georgia Regents University, Augusta, GA USA.
Christine Cole JohnsonDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Germaine J M YongDepartment of Medicine, University of California, San Francisco, CA USA.
Ganesa WegienkaDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.
Andrea E Cassidy-BushrowDepartment of Public Health Sciences, Henry Ford Hospital, 1 Ford Place, 5C, Detroit, MI 48202 USA.ORCID 0000-0001-8272-4448

Funding

The Effect of Dog-Keeping and the Intestinal Microbiota on Immune DevelopmentP01AI089473 · NIAID · HENRY FORD HEALTH SYSTEM · PI OWNBY, DENNIS R · 2012 to 2024
$25.7M
Delivery mode, environment and the gut microbiome: influence on childhood body sizeR01HD082147 · NICHD · HENRY FORD HEALTH SYSTEM · PI CASSIDY-BUSHROW, ANDREA E · 2016 to 2020
$3.0M
Early Environmental Hygiene and Pediatric AtopyR01AI050681 · NIAID · HENRY FORD HEALTH SYSTEM · PI JOHNSON, CHRISTINE C · 2002 to 2006
$2.9M
Early Environmental Hygiene and Pediatric AsthmaR56AI050681 · NIAID · HENRY FORD HEALTH SYSTEM · PI JOHNSON, CHRISTINE C · 2008 to 2009
$1.5M
EARLY LIFE VITAMIN D, RACIAL DISPARITIES, AND WHEEZINGR01HL113010 · NHLBI · HENRY FORD HEALTH SYSTEM · PI WEGIENKA, GANESA REBECCA · 2012 to 2014
$1.2M
NHLBI NIH HHS R01 HL113010NIAID NIH HHS P01 AI089473NIAID NIH HHS R01 AI050681NIAID NIH HHS R56 AI050681NICHD NIH HHS R01 HD082147
6 · The paper itself

Abstract

backgroundMounting evidence suggests both vitamin D and the early life gut microbiome influence childhood health outcomes. However, little is known about how these two important exposures are related. We aimed to examine associations between plasma 25-hydroxyvitamin D (25[OH]D) levels during pregnancy or at delivery (cord blood) and infant gut microbiota.

methodsMaternal and cord blood 25[OH]D levels were assessed in a sample of pregnant women. Compositional analyses adjusted for race were run on the gut microbiota of their offspring at 1 and 6 months of age.

resultsMean prenatal 25(OH)D level was 25.04 ± 11.62 ng/mL and mean cord blood 25(OH)D level was 10.88 ± 6.77 ng/mL. Increasing prenatal 25(OH)D level was significantly associated with decreased richness (

conclusionsPrenatal maternal and cord blood 25(OH)D levels are associated with the early life gut microbiota. Future studies are needed to understand how vitamin D and the microbiome may interact to influence child health.

Indexed as

Birth cohortCord bloodGut microbiotaVitamin D

Identifiers

PMID33101701
PMCPMC7576815

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.