ArticleCanadian journal of kidney health and disease2020
Graft Function, Albuminuria, and the Risk of Hemorrhage and Thrombosis After Kidney Transplantation.
Article in Canadian journal of kidney health and disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 3 citations in OpenAlex.
- Follow-up Care of Critically Ill Patients With Acute Kidney Injury: A Cohort Study.Kidney medicine · 2023Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCompared to the general population, kidney transplant recipients are at increased risk of hemorrhage and thrombosis. Whether this risk is affected by graft function and albuminuria is unknown.
objectiveTo determine the association between graft function and albuminuria and the risk of post-transplant hemorrhage and thrombosis.
designRetrospective cohort study.
settingWe used linked health care databases in Alberta, Canada. PATIENTS/SAMPLE/
participantsWe included adult kidney transplant recipients from 2002 to 2015 with a functioning graft at 1 year. MEASUREMENTS: Estimated glomerular filtration rate (eGFR) and albuminuria measurements at 1 year post-transplant were used to categorize recipients (eGFR: ≥45 vs. <45 mL/min/1.73 m
methodsWe determined the association between categories of eGFR and albuminuria and post-transplant hemorrhage and venous thrombosis using Poisson regression with log link.
resultsOf 1284 kidney transplant recipients, 21% had an eGFR <45 mL/min/1.73 m LIMITATIONS: Complete relevant medication information, such as anticoagulants, were not available in our datasets. Due to sample size, this study was underpowered to conduct a fully adjusted analysis.
conclusionAmong kidney transplant recipients, lower eGFR and presence of albuminuria at 1 year post-transplant were associated with an over 2-fold higher risk of hemorrhage and venous thrombosis. Graft function and albuminuria at 1 year post-transplant are important prognostic factors in determining risk of post-transplant hemorrhage and venous thrombosis. Further research, including medication data, are needed to further delineate outcomes and safety.
trial registrationNot applicable (cohort study).
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