Evidence map›Paper›PMID 33101678›Full record

ArticleClinical & translational immunology2020

Koon H Lee, Kavitha Gowrishankar, Janine Street, Helen M McGuire, Fabio Luciani, Brendan Hughes, Mandeep Singh, Leighton E Clancy, David J Gottlieb, Kenneth P Micklethwaite and 1 more

Open access · goldAbstract read
In one paragraph

Article in Clinical & translational immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Increasing Role of Targeted Immunotherapies in the Treatment of AML.International journal of molecular sciences · 2022
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 1 country.

Koon H LeeWestmead Institute for Medical Research Westmead NSW Australia.ORCID https://orcid.org/0000-0001-9541-3876
Kavitha GowrishankarWestmead Institute for Medical Research Westmead NSW Australia.
Janine StreetWestmead Institute for Medical Research Westmead NSW Australia.
Helen M McGuireFaculty of Medicine and Health Sydney Medical School Sydney NSW Australia.ORCID https://orcid.org/0000-0003-2047-6543
Fabio LucianiThe Kirby Institute University of New South Wales Darlinghurst NSW Australia.
Brendan HughesThe Kirby Institute University of New South Wales Darlinghurst NSW Australia.
Mandeep SinghThe Garvan Institute of Medical Research Darlinghurst NSW Australia.
Leighton E ClancyWestmead Institute for Medical Research Westmead NSW Australia.
David J GottliebWestmead Institute for Medical Research Westmead NSW Australia.
Kenneth P MicklethwaiteWestmead Institute for Medical Research Westmead NSW Australia.
Emily BlythWestmead Institute for Medical Research Westmead NSW Australia.ORCID https://orcid.org/0000-0002-7849-7139
Westmead Hospital · AUUNSW Sydney · AUWestmead Institute for Medical Research · AUGarvan Institute of Medical Research · AUSydney Local Health District · AUThe University of Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdoptive immunotherapy with

methodsMononuclear cells were pulsed with PRAME 15-mer overlapping peptide mix. After 16 h, activated cells expressing CD137 were isolated with immunomagnetic beads and cocultured with irradiated CD137

resultsPRAME-stimulated cultures (

conclusionPRAME-specific T cells for adoptive immunotherapy were enriched from healthy donor mononuclear cells. The products were oligoclonal, exhibited Th1 phenotype and produced multiple cytokines.

Indexed as

adoptive immunotherapyantigen‐specific T cellsPRAMEpreferential expressed antigen in melanoma

Identifiers

PMID33101678
PMCPMC7577233
OpenAlexW3093943597

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.