ArticleNeural plasticity2020
Aberrant Advanced Cognitive and Attention-Related Brain Networks in Parkinson's Disease with Freezing of Gait.
Article in Neural plasticity, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 17 citations in OpenAlex.
- The association of glymphatic system function with cognitive decline in PD-FOG: multimodal MRI evidence from cross-sectional and longitudinal studies.Brain imaging and behavior · 2025Article
- Fist-Palm Test May Identify Mild Cognitive Impairment and Freezing of Gait in Parkinson's Disease: A Machine Learning Approach.Movement disorders clinical practice · 2025Article
- Distinctive Gait Variations and Neuroimaging Correlates in Alzheimer's Disease and Cerebral Small Vessel Disease.Journal of cachexia, sarcopenia and muscle · 2024Article
- Emotional auditory stimuli influence step initiation in Parkinson's disease with freezing of gait.Scientific reports · 2024Article
- Top-down control of human motor thalamic neuronal activity during the auditory oddball task.NPJ Parkinson's disease · 2023Article
- Impaired structural and reserved functional topological organizations of brain networks in Parkinson's disease with freezing of gait.Quantitative imaging in medicine and surgery · 2023Article
- Large-scale frontoparietal theta, alpha, and beta phase synchronization: A set of EEG differential characteristics for freezing of gait in Parkinson's disease?Frontiers in aging neuroscience · 2022Article
- Freezing of Gait in Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- Comparing the Clinical and Neuropsychological Characteristics of Parkinson's Disease With and Without Freezing of Gait.Frontiers in neuroscience · 2021Article
- Role of prefrontal cortex in freezing of gait in Parkinson's disease: mechanisms and neuroimaging evidence.Frontiers in neurologyReview
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Freezing of gait (FOG) is a disabling gait disorder influencing patients with Parkinson's disease (PD). Accumulating evidence suggests that FOG is related to the functional alterations within brain networks. We investigated the changes in brain resting-state functional connectivity (FC) in patients with PD with FOG (FOG+) and without FOG (FOG-). Methods: Resting-state functional magnetic resonance imaging (RS-fMRI) data were collected from 55 PD patients (25 FOG+ and 30 FOG-) and 26 matched healthy controls (HC). Differences in intranetwork connectivity between FOG+, FOG-, and HC individuals were explored using independent component analysis (ICA). Results: Seven resting-state networks (RSNs) with abnormalities, including motor, executive, and cognitive-related networks, were found in PD patients compared to HC. Compared to FOG- patients, FOG+ patients had increased FC in advanced cognitive and attention-related networks. In addition, the FC values of the auditory network and default mode network were positively correlated with the Gait and Falls Questionnaire (GFQ) and Freezing of Gait Questionnaire (FOGQ) scores in FOG+ patients. Conclusions: Our findings suggest that the neural basis of PD is associated with impairments of multiple functional networks. Notably, alterations of advanced cognitive and attention-related networks rather than motor networks may be related to the mechanism of FOG.
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