Evidence map›Paper›PMID 33101399›Full record

ArticleThe journal of venomous animals and toxins including tropical diseases2020

Venom complexity of

Daniela Miki Hatakeyama, Lídia Jorge Tasima, Cesar Adolfo Bravo-Tobar, Caroline Serino-Silva, Alexandre Keiji Tashima, Caroline Fabri Bittencourt Rodrigues, Weslei da Silva Aguiar, Nathália da Costa Galizio, Eduardo Oliveira Venancio de Lima, Victor Koiti Kavazoi and 6 more

Open access · goldAbstract read
In one paragraph

Article in The journal of venomous animals and toxins including tropical diseases, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 40 citations in OpenAlex.

  1. Venomics across theJournal of proteome research · 2026
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  5. Analysis of the genusHeliyon · 2024
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  9. Toxins · 2023
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  13. Crosstalk of Inflammation and Coagulation inInternational journal of molecular sciences · 2023
    Review
  14. Review
  15. Article
  16. Hybridization betweenBiology · 2022
    Article
  17. Venom composition ofThe journal of venomous animals and toxins including tropical diseases · 2022
    Article
  18. Review
  19. Bleeding and Thrombosis: Insights into Pathophysiology ofInternational journal of molecular sciences · 2021
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Daniela Miki HatakeyamaLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Lídia Jorge TasimaLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Cesar Adolfo Bravo-TobarLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Caroline Serino-SilvaLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Alexandre Keiji TashimaDepartment of Biochemistry, Federal University of São Paulo (Unifesp), São Paulo, SP, Brazil.ORCID 0000-0002-1332-8895
Caroline Fabri Bittencourt RodriguesLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Weslei da Silva AguiarLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Nathália da Costa GalizioLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Eduardo Oliveira Venancio de LimaLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Victor Koiti KavazoiLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Juan David Gutierrez-MarínLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Iasmim Baptista de FariasLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Sávio Stefanini Sant'AnnaLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.
Kathleen Fernandes GregoLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0003-4769-5818
Karen de Morais-ZaniLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0001-9900-8384
Anita Mitico Tanaka-AzevedoLaboratory of Herpetology, Butantan Institute, São Paulo, SP, Brazil.ORCID 0000-0002-4694-4475
Instituto Butantan · BRUniversidade Federal de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVariability in snake venoms is a well-studied phenomenon. However, sex-based variation of

methodsVenoms were collected from five females and four males born from a snake captured from the wild in São Bento (Maranhão, Brazil), and kept in the Laboratory of Herpetology of Butantan Intitute. The venoms were analyzed individually and as a pool of each gender. The assays consisted in protein quantification, 1-DE, mass spectrometry, proteolytic, phospholipase A

resultsElectrophoretic profiles of male's and female's venom pools were quite similar, with minor sex-based variation. Male venom showed higher LAAO, PLA

conclusionAlthough differences between female and male venoms were observed, our results show that individual variations are significant even between siblings, highlighting that biological activities of venoms and its composition are influenced by other factors beyond gender.

Indexed as

Bothrops atroxEnvenomationIndividual variationSnake venom

Identifiers

PMID33101399
PMCPMC7553035
OpenAlexW3094616787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.