Evidence map›Paper›PMID 33101318›Full record

ArticleFrontiers in immunology2020

Maresin-1 and Resolvin E1 Promote Regenerative Properties of Periodontal Ligament Stem Cells Under Inflammatory Conditions.

Emmanuel Albuquerque-Souza, Fabian Schulte, Tsute Chen, Markus Hardt, Hatice Hasturk, Thomas E Van Dyke, Marinella Holzhausen, Alpdogan Kantarci

RetractedOpen access · goldAbstract readRetracted Publication
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 44 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 2 pooled it
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 2 syntheses or guidelines pooled it, 66 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. General View of Arachidonic Acid (AA) Metabolism.Reviews of physiology, biochemistry and pharmacology · 2027
    Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. [Research Progress on the Role and Regulatory Mechanisms of Lipid Metabolism in the Osteogenic/Odontogenic Differentiation of Dental Stem Cells].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Novel lipid mediator 7Frontiers in cell and developmental biology · 2024
    Article
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Emmanuel Albuquerque-SouzaThe Forsyth Institute, Cambridge, MA, United States.
Fabian SchulteThe Forsyth Institute, Cambridge, MA, United States.
Tsute ChenThe Forsyth Institute, Cambridge, MA, United States.
Markus HardtThe Forsyth Institute, Cambridge, MA, United States.
Hatice HasturkThe Forsyth Institute, Cambridge, MA, United States.
Thomas E Van DykeThe Forsyth Institute, Cambridge, MA, United States.
Marinella HolzhausenDivision of Periodontics, Department of Stomatology, School of Dentistry, University of São Paulo, São Paulo, Brazil.
Alpdogan KantarciThe Forsyth Institute, Cambridge, MA, United States.
Harvard University · USUniversidade de São Paulo · BR

Funding

Mechanisms of Resolvin E1 in Periodontal RegenerationR01DE025020 · NIDCR · ADA FORSYTH INSTITUTE, INC. · PI GUASTALDI, FERNANDO, VAN DYKE, THOMAS ELLIOTT · 2015 to 2023
$4.9M
Mechanistic link between Alzheimer's disease and periodontitisRF1AG062496 · NIA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI DEDEOGLU, ALPASLAN, KANTARCI, IBRAHIM ALPDOGAN · 2019 to 2019
$3.7M
NIA NIH HHS RF1 AG062496NIDCR NIH HHS R01 DE025020
6 · The paper itself

Abstract

Maresin-1 (MaR1) and Resolvin E1 (RvE1) are specialized pro-resolving lipid mediators (SPMs) that regulate inflammatory processes. We have previously demonstrated the hard and soft tissue regenerative capacity of RvE1 in an

Indexed as

Cells, CulturedDocosahexaenoic AcidsEicosapentaenoic AcidHumansInflammationPeriodontal LigamentRegenerationStem Cells5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acidDocosahexaenoic AcidsEicosapentaenoic AcidinflammationMaresin 1Omega 3 (n–3) polyunsaturated fatty acidsResolvin E1stem cells

Identifiers

PMID33101318
PMCPMC7546375
OpenAlexW3089315332

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.