Evidence map›Paper›PMID 33101280›Full record

ArticleFrontiers in immunology2020

Local and Systemic Concentrations of Pattern Recognition Receptors of the Lectin Pathway of Complement in a Cohort of Patients With Interstitial Lung Diseases.

Severin Vogt, Marten Trendelenburg, Michael Tamm, Daiana Stolz, Katrin Esther Hostettler, Michael Osthoff

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.6field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. The Role of Ficolins in Lung Injury.Journal of innate immunity · 2024
    Review
  6. Review
  7. Article
  8. Article
  9. PTX3 in Granuloma Formation and Sarcoidosis: Helping Macrophages Accept a "Complement".American journal of respiratory and critical care medicine · 2022
    Article
  10. Article
  11. Cell surface (Amsterdam, Netherlands) · 2021
    Article
  12. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Severin VogtDivision of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
Marten TrendelenburgDivision of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
Michael TammDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Daiana StolzDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Katrin Esther HostettlerDepartment of Biomedicine, University of Basel, Basel, Switzerland.
Michael OsthoffDivision of Internal Medicine, University Hospital of Basel, Basel, Switzerland.
University Hospital of Basel · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The role of the lectin pathway of complement in the pathogenesis of interstitial lung diseases (ILDs) is largely unknown. Pattern recognition receptors (PRR) of the lectin pathway are involved in the clearance of apoptotic cells either via activation of the complement system or as direct opsonins. As recent findings suggest a role of apoptosis in the development of pulmonary fibrosis, the influence of plasma lectins has lately been considered in various ILDs, but data on local concentrations in the lungs are lacking. This study investigated the role of mannose-binding lectin (MBL), ficolin-2 and ficolin-3 in ILD patients with a focus on idiopathic pulmonary fibrosis (IPF) and sarcoidosis. Methods: A case control study was conducted involving 80 patients with different forms of ILD as well as 40 control patients undergoing routine flexible bronchoscopy with bronchoalveolar lavage (BAL). Plasma and BAL fluid (BALF) levels of MBL, ficolin-2 and ficolin-3 as well as complement split products C4d and C5a (only in BALF) were measured by enzyme-linked immunosorbent assays. Eight single-nucleotide polymorphisms (SNPs) of MBL and ficolin-2 were determined by genotyping and tested for their association with ILDs. Results: We included 35, 35, 10, and 40 patients with sarcoidosis, idiopathic pulmonary fibrosis (IPF), other ILD, and a control group, respectively. BALF but not plasma levels of the three PRR were significantly elevated in sarcoidosis patients compared to a control group without ILD (MBL: median 66.8 vs. 24.6 ng/ml, Conclusion: This is the first study to simultaneously assess systemic and local lectin pathway protein levels in ILD patients. Our data suggest an involvement of PRR of the lectin pathway in the pathogenesis of sarcoidosis given the significantly higher BALF levels compared to a control group. Additional analyses in a larger patient cohort are required to confirm or refute a potential effect of local and/or systemic ficolin-2 levels in IPF patients.

Indexed as

AdultAgedAged, 80 and overBronchoalveolar LavageCase-Control StudiesCohort StudiesComplement System ProteinsFemaleFicolinsGenotypeHumansIdiopathic Pulmonary FibrosisLectinsLung Diseases, InterstitialMaleMannose-Binding LectinComplement System ProteinsFCN3 protein, humanFicolinsLectinsMannose-Binding LectinMBL2 protein, humanReceptors, Pattern Recognitionbronchoalveolar lavage fluidcomplement systemficolin-2ficolin-3idiopathic pulmonary fibrosisinterstitial lung diseasemannose-binding lectinsarcoidosis

Identifiers

PMID33101280
PMCPMC7546814
OpenAlexW3088216734

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.