Evidence map›Paper›PMID 33101265›Full record

ArticleFrontiers in immunology2020

Cytomegalovirus-Mediated T Cell Receptor Repertoire Perturbation Is Present in Early Life.

Meriem Attaf, Julia Roider, Amna Malik, Cristina Rius Rafael, Garry Dolton, Andrew J Predergast, Alasdair Leslie, Thumbi Ndung'u, Henrik N Kløverpris, Andrew K Sewell and 1 more

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 8 institutions in 5 countries.

Meriem AttafDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Julia RoiderHuman Immunodeficiency Virus Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Amna MalikDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Cristina Rius RafaelDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Garry DoltonDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Andrew J PredergastZvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.
Alasdair LeslieAfrica Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Thumbi Ndung'uHuman Immunodeficiency Virus Pathogenesis Programme, Doris Duke Medical Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Henrik N KløverprisAfrica Health Research Institute, Nelson R. Mandela School of Medicine, University of KwaZulu-Natal, Durban, South Africa.
Andrew K SewellDivision of Infection and Immunity, Cardiff University School of Medicine, Cardiff, United Kingdom.
Philip J GoulderDepartment of Paediatrics, University of Oxford, Oxford, United Kingdom.
Cardiff University · GBAfrica Health Research Institute · ZAGerman Center for Infection Research · DEJohns Hopkins University · USMax Planck Institute for Infection Biology · DERagon Institute of MGH, MIT and Harvard · USUniversity College London · GBUniversity of Oxford · GB

Funding

Maximising Cure Potential in Paediatric HIV InfectionR01AI133673 · NIAID · UNIVERSITY OF OXFORD · PI GOULDER, PHILIP J · 2017 to 2021
$1.4M
NIAID NIH HHS R01 AI133673Wellcome TrustWellcome Trust 202485/Z/16/ZWellcome Trust PG WT104748MAWellcome Trust WT100327MA
6 · The paper itself

Abstract

Human cytomegalovirus (CMV) is a highly prevalent herpesvirus, particularly in sub-Saharan Africa, where it is endemic from infancy. The T cell response against CMV is important in keeping the virus in check, with CD8 T cells playing a major role in the control of CMV viraemia. Human leukocyte antigen (HLA) B

Indexed as

AdolescentAdultAge FactorsAntigens, ViralCD8-Positive T-LymphocytesChildChild, PreschoolCoinfectionCytomegalovirusCytomegalovirus InfectionsEpitopes, T-LymphocyteFemaleHigh-Throughput Nucleotide SequencingHIV InfectionsHLA AntigensHumansAntigens, ViralEpitopes, T-LymphocyteHLA AntigensPeptidesReceptors, Antigen, T-CellcytomegalovirusHLA-B*44:03memory inflationpaediatric repertoirerepertoire dynamicssuperdominanceT cell receptorT cell receptor repertoire

Identifiers

PMID33101265
PMCPMC7554308
OpenAlexW3043315054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.