ArticleFrontiers in microbiology2020
Epidemiology and Genetic Characterization of Classical Human Astrovirus Infection in Shanghai, 2015-2016.
Article in Frontiers in microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 24 citations in OpenAlex.
- Molecular characterization and genotypic diversity of human astroviruses among patients with gastroenteritis in Saudi Arabia, 2022-2023.Virus genes · 2026Article
- Prevalence of astrovirus-associated gastroenteritis among hospitalized pediatric patients in Asia: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Review
- Organoids Gone Viral: A Comprehensive Review on Human Organoid Models to Study Viral Pathogenesis.Viruses · 2026Review
- Astrovirus in the Brazilian Amazon: First detection of non-classical astroviruses (MLB-3) in the Americas.PloS one · 2026Article
- Comparison of classic and novel human astrovirus MLB and VA seroprevalence in HIV and non-HIV cohorts in South China demonstrates high seroreactivity to classic human astrovirus, which is associated with HIV infection.Microbiology spectrum · 2025Article
- Viral metagenomics reveals diverse viruses in the fecal samples of children with acute respiratory infection.Frontiers in microbiology · 2025Article
- Genomic analysis of an acute gastroenteritis outbreak caused by rotavirus C in Hebei, China.Virology journal · 2024Article
- Epidemiology of Pediatric Astrovirus Gastroenteritis in a Nicaraguan Birth Cohort.Open forum infectious diseases · 2024Article
- Article
- Characterisation of human astrovirus in a diarrhoea outbreak using nanopore and Sanger sequencing protocols.Virology journal · 2023Article
- Diversity of classic and novel human astrovirus in outpatient children with acute gastroenteritis in Shanghai, China.Frontiers in microbiology · 2023Article
- Viral metagenomics reveals diverse viruses in the fecal samples of children with diarrhea.Virologica Sinica · 2022Article
- Molecular Epidemiology of Human Adenovirus, Astrovirus, and Sapovirus Among Outpatient Children With Acute Diarrhea in Chongqing, China, 2017-2019.Frontiers in pediatrics · 2022Article
- High divergence of human astrovirus genotypes circulating in pediatric patients hospitalized with acute gastroenteritis in Chiang Mai, Thailand, 2017-2020.Scientific reports · 2021Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveHuman astroviruses (HAstVs) are single-stranded RNA viruses of the
methodsA total of 6,051 non-redundant stool samples were collected in outpatients with acute diarrhea in Shanghai from January 2015 to December 2016. One-step real-time RT-PCR was used for screening viral diarrhea, including rotavirus A, rotavirus B, rotavirus C, norovirus genotype I and II, classic human astroviruses, and sapovirus. Real-time PCR was used for screening human enteric adenoviruses. Conventional RT-PCR was used for the amplification of viral fragments for genotyping. PCR products were sequenced and used for the construction of phylogenetic trees.
resultsThe detection rate of classic HAstVs was 1.55% (94/6,051). The prevalence of HAstV infection displayed a typical winter/spring (December to March) seasonality and was highest in the 5-14 age group. Eighty-six samples were genotyped, which revealed HAstV-1 as the most prevalent genotype, followed by HAstV-5, HAstV-4, HAstV- 2, HAstV-8, and HAstV-3. There was a dramatic rise in the prevalence of HAstV-4 from December 2015 to March 2016, and the viral loads of HAstV-4 were significantly higher than those of other genotypes. Among the mixed infection samples, noroviruses were found to be the most frequently co-infected enteric viruses with HAstV.
conclusionMultiple genotypes of classic HAstVs circulated in Shanghai from January 2015 to December 2016. For the first time, HAstV-3\4\5\8 were detected in Shanghai.
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