Evidence map›Paper›PMID 33101065›Full record

ArticleFrontiers in physiology2020

TFII-I/Gtf2i and Erythro-Megakaryopoiesis.

Aishwarya Gurumurthy, Qiong Wu, Rukiye Nar, Kimberly Paulsen, Alexis Trumbull, Ryan C Fishman, Marjorie Brand, John Strouboulis, Zhijian Qian, Jörg Bungert

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Heterozygous nonsenseResearch and practice in thrombosis and haemostasis · 2025
    Article
  3. Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

Aishwarya GurumurthyDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
Qiong WuDivision of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, FL, United States.
Rukiye NarDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
Kimberly PaulsenDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
Alexis TrumbullDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
Ryan C FishmanDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
Marjorie BrandSprott Center for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, ON, Canada.
John StrouboulisComprehensive Cancer Center, School of Cancer and Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, United Kingdom.
Zhijian QianDivision of Medicine and Department of Biochemistry and Molecular Biology, UF Health Cancer Center, University of Florida, Gainesville, FL, United States.
Jörg BungertDepartment of Biochemistry and Molecular Biology, College of Medicine, UF Health Cancer Center, Genetics Institute, Powell Gene Therapy Center, University of Florida, Gainesville, FL, United States.
University of Florida · USUniversity of Florida Health · USKing's College London · GBOttawa Hospital · CA

Funding

Transcriptional Control During ErythropoiesisR01DK098449 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Marjorie Carole Brand, JEFFREY A RANISH · 2013 to 2026
$5.8M
The role of EVI1-induced hypermethylation in leukemogenesis.R01HL131444 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI QIAN, ZHIJIAN · 2016 to 2019
$1.6M
The molecular mechanism of clonal dominance in 5q(del) MDSR01DK107615 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI QIAN, ZHIJIAN · 2016 to 2019
$1.4M
Functional proteomic and genomic analysis of transcription factor TFII-I in erythroid cellsR56DK111439 · NIDDK · UNIVERSITY OF FLORIDA · PI BUNGERT, JORG · 2018 to 2018
$100k
NHLBI NIH HHS R01 HL131444NIDDK NIH HHS R01 DK098449NIDDK NIH HHS R01 DK107615NIDDK NIH HHS R56 DK111439
6 · The paper itself

Abstract

TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer. Williams-Beuren Syndrome (WBS) is caused by a large hemizygous deletion on chromosome 7q11.23 which encompasses 26-28 genes, including

Indexed as

erythropoiesisglobinGtf2imegakaryopoiesisTFII-Itranscription factor

Identifiers

PMID33101065
PMCPMC7546208
OpenAlexW3088632494

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.