ArticleFrontiers in pharmacology2020
Image-Guided Treatment of Primary Liver Cancer in Mice Leads to Vascular Disruption and Increased Drug Penetration.
Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Effect of Ultrasound Combined with Microbubbles on Blood Perfusion in Invasive Breast Cancer-A Prospective Clinical Trial.Technology in cancer research & treatmentTrial
- Transient tumor perfusion loss: evaluating the spatial and temporal dynamics of blood flow changes induced by ultrasound cavitation treatments.Ultrasonics · 2026Article
- Blood‒brain barrier opening with Golay-coded ultrasound to improve therapeutic consistency in glioblastoma models.Drug delivery · 2025Article
- Delivery of Cavitation Therapy With a Modified Clinical Scanner: In Vitro Evaluation.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Controlled Hyperthermia With High-Intensity Focused Ultrasound and Ultrasound Contrast Agent Microbubbles in Porcine Liver.Ultrasound in medicine & biology · 2023Article
- Microbubble-Assisted Ultrasound for Drug Delivery to the Retina in an Ex Vivo Eye Model.Pharmaceutics · 2023Article
- Intravital imaging and cavitation monitoring of antivascular ultrasound in tumor microvasculature.Theranostics · 2023Article
- Ultrasound and Nanomedicine for Cancer-Targeted Drug Delivery: Screening, Cellular Mechanisms and Therapeutic Opportunities.Pharmaceutics · 2022Review
- Enhanced tumor penetration for efficient chemotherapy by a magnetothermally sensitive micelle combined with magnetic targeting and magnetic hyperthermia.Frontiers in pharmacology · 2022Article
- Ultrasound and Microbubbles for the Treatment of Ocular Diseases: From Preclinical Research towards Clinical Application.Pharmaceutics · 2021Review
- Effects of contrast-enhanced ultrasound treatment on neoadjuvant chemotherapy in breast cancer.Theranostics · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite advances in interventional procedures and chemotherapeutic drug development, hepatocellular carcinoma (HCC) is still the fourth leading cause of cancer-related deaths worldwide with a <30% 5-year survival rate. This poor prognosis can be attributed to the fact that HCC most commonly occurs in patients with pre-existing liver conditions, rendering many treatment options too aggressive. Patient survival rates could be improved by a more targeted approach. Ultrasound-induced cavitation can provide a means for overcoming traditional barriers defining drug uptake. The goal of this work was to evaluate preclinical efficacy of image-guided, cavitation-enabled drug delivery with a clinical ultrasound scanner. To this end, ultrasound conditions (unique from those used in imaging) were designed and implemented on a Philips EPIQ and S5-1 phased array probe to produced focused ultrasound for cavitation treatment. Sonovue
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.