Evidence map›Paper›PMID 33100996›Full record

ArticleFrontiers in human neuroscience2020

Effects of High-Definition Transcranial Direct-Current Stimulation on Resting-State Functional Connectivity in Patients With Disorders of Consciousness.

Rui Zhang, Lipeng Zhang, Yongkun Guo, Li Shi, Jinfeng Gao, Xinjun Wang, Yuxia Hu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.9field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

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  17. The 2020 Yearbook of Neurorestoratology.Journal of neurorestoratology · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 1 country.

Rui ZhangSchool of Electrical Engineering, Zhengzhou University, Zhengzhou, China.
Lipeng ZhangSchool of Electrical Engineering, Zhengzhou University, Zhengzhou, China.
Yongkun GuoThe Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li ShiDepartment of Automation, Tsinghua University, Beijing, China.
Jinfeng GaoSchool of Electrical Engineering, Zhengzhou University, Zhengzhou, China.
Xinjun WangThe Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yuxia HuSchool of Electrical Engineering, Zhengzhou University, Zhengzhou, China.
Guangxi Zhuang Autonomous Region Brain Hospital · CNZhengzhou University · CNFifth Affiliated Hospital of Zhengzhou University · CNNational Engineering Research Center for Information Technology in Agriculture · CNZhengzhou Central Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently a positive treatment effect on disorders of consciousness (DOCs) with high-definition transcranial direct-current stimulation (HD-tDCS) has been reported; however, the neural modulation mechanisms of this treatment's efficacy need further investigation. To better understand the processing of HD-tDCS interventions, a long-lasting HD-tDCS protocol was applied to 15 unresponsive wakefulness syndrome (UWS) patients and 20 minimally conscious states (MCS) patients in this study. Ten minutes of resting-state electroencephalograms (EEGs) were recorded from the patients, and the coma recovery scale-revised scores (CRS-Rs) were assessed for each patient from four time-points (T0, T1, T2, and T3). Brain networks were constructed by calculating the EEG spectral connectivity using the debiased weighted phase lag index (dwPLI) and then quantified the network information transmission efficiency by graph theory. We found that there was an increasing trend in local and global information processing of beta and gamma bands in resting-state functional brain networks during the 14 days of HD-tDCS modulation for MCS patients. Furthermore, the increased functional connectivity not only occurred in the local brain area surrounding the stimulation position but was also present across more global brain areas. Our results suggest that long-lasting HD-tDCS on the precuneus may facilitate information processing among neural populations in MCS patients.

Indexed as

coma recovery scale-revised scoresdisorders of consciousnesselectroencephalographyhigh-definition transcranial direct-current stimulationresting-state brain network

Identifiers

PMID33100996
PMCPMC7546763
OpenAlexW3088864281

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.