Evidence map›Paper›PMID 33100983›Full record

ArticleFrontiers in human neuroscience2020

Effects of Nicotine Gum Administration on Vision (ENIGMA-Vis): Study Protocol of a Double-Blind, Randomized, and Controlled Clinical Trial.

Thiago P Fernandes, Jeffery K Hovis, Natalia Almeida, Jandirlly J S Souto, Thiago Augusto Bonifacio, Stephanye Rodrigues, Gabriella Medeiros Silva, Michael Oliveira Andrade, Jessica Bruna Silva, Giulliana H Gomes and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Facial processing in bipolar disorder is mediated by clinical and biological aspects.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Thiago P FernandesDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Jeffery K HovisSchool of Optometry and Vision Science, University of Waterloo, Waterloo, ON, Canada.
Natalia AlmeidaDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Jandirlly J S SoutoDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Thiago Augusto BonifacioDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Stephanye RodriguesDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Gabriella Medeiros SilvaDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Michael Oliveira AndradePerception, Neuroscience and Behaviour Laboratory, Department of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Jessica Bruna SilvaPerception, Neuroscience and Behaviour Laboratory, Department of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Giulliana H GomesMedical Sciences College, João Pessoa, Brazil.
Milena Edite OliveiraDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Eveline Holanda LimaDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Maria Eduarda GomesDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Marcos V A JuniorDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Mariana Lopes MartinsDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Natanael A SantosDepartment of Psychology, Federal University of Paraiba, João Pessoa, Brazil.
Universidade Federal da Paraíba · BRCentro Universitário de João Pessoa · BRUniversidade do Estado de Minas Gerais · BRUniversity of Waterloo · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Studies reported that tobacco addiction was related to visual impairments, but one unresolved issue is whether the impairments are related to the many compounds existing in the cigarettes or to the effects of nicotine. On the other hand, nicotine gum can be used as replacement therapy or as a neuroprotective agent for some diseases. The main purpose of this controlled trial is to investigate the effects of nicotine gum on vision. The ENIGMA-Vis trial aims to compare two dosages of nicotine gum (2 and 4 mg) and a placebo gum in a randomized, double-blind, placebo-controlled trial of 100 participants to be allocated into a single group assignment of repeated measures (two studies;

Indexed as

clinical trialnicotinenicotine gumpsychopharmacologysmokingvisual processing

Identifiers

PMID33100983
PMCPMC7506462
OpenAlexW3084287976

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.