Evidence map›Paper›PMID 33100754›Full record

ArticleUrology annals

Relation of baseline prostate volume to improvement of lower urinary tract symptoms due to tamsulosin monotherapy in benign prostatic hyperplasia: An exploratory, multicenter, prospective study.

Mahmoud Shoukry El-Adawy, Ahmed Yehia Abdelaziz, Ahmed Salem, Waseem Aboul Ela, Ayman Salah Moussa, Rabee Ibrahim, Fouad Zanaty, Mohamed H Abdelhamid, Hussien Aldaqadossi, Ahmed M Ragheb and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Urology annals. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Mahmoud Shoukry El-AdawyDepartment of Urology, Fayoum University, Fayoum, Egypt.
Ahmed Yehia AbdelazizDepartment of Urology, Cairo University, Cairo, Egypt.
Ahmed SalemDepartment of Urology, Cairo University, Cairo, Egypt.
Waseem Aboul ElaDepartment of Urology, Cairo University, Cairo, Egypt.
Ayman Salah MoussaDepartment of Urology, Beni-Suef University, Beni-Suef, Egypt.
Rabee IbrahimDepartment of Urology, Beni-Suef University, Beni-Suef, Egypt.
Fouad ZanatyDepartment of Urology, Menoufia University, Menoufia, Egypt.
Mohamed H AbdelhamidDepartment of Urology, Cairo University, Cairo, Egypt.
Hussien AldaqadossiDepartment of Urology, Fayoum University, Fayoum, Egypt.
Ahmed M RaghebDepartment of Urology, Beni-Suef University, Beni-Suef, Egypt.
Hossam A ShakerDepartment of Urology, Fayoum University, Fayoum, Egypt.
Sameh KotbDepartment of Urology, Cairo University, Cairo, Egypt.
Fayoum University · EGCairo University · EGBeni-Suef University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe aim of the study was to investigate the relation between baseline prostate volume (PV) and the improvement of lower urinary tract symptoms (LUTS) induced by tamsulosin monotherapy after 2-year follow-up in Egyptian benign prostatic hyperplasia (BPH) patients. SETTINGS AND

designThis was a prospective comparative multicenter study. SUBJECTS AND

methodsThree hundred and eighty-one BPH patients were included in the study from January 2014 to January 2017. The patients were divided according to their PV into two groups. Group A included patients with small-sized prostate (≤40 ml) and Group B included those with PV larger than 40 ml. Full evaluation was done at presentation. The patients are followed up at 6, 12, and 24 months of continued medical treatment with tamsulosin 0.4 mg once daily. STATISTICAL ANALYSIS USED: Data were coded and entered using the Statistical Package for the Social Sciences version 24. Data were summarized using mean and standard deviation in quantitative data. Comparisons between quantitative variables were done using unpaired

resultsThe mean age was 60.1 ± 7.2 years. The mean value of the International Prostate Symptom Score (IPSS) was recorded for the 381 patients at presentation. In Group A, the mean value of IPSS was 20.44 ± 3.18, whereas in Group B, the mean value of IPSS was 21.23 ± 3.5. There was a significant improvement in symptoms (Q

conclusionsPV is an important prognostic factor affecting the improvement of the LUTS by α1-blocker monotherapy. Tamsulosin monotherapy may not be enough for large prostate (>40 mg) to maintain adequate symptom relief, and it is better to start with other medical options such as combined therapy or early nonmedical therapy. Starting α1-blocker monotherapy in smaller prostates may be of benefit in symptomatic patients without considering watchful waiting.

Indexed as

Benign prostatic hyperplasialower urinary tract symptomsprostate volumetamsulosin monotherapy

Identifiers

PMID33100754
PMCPMC7546079
OpenAlexW3043795714

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.