Evidence map›Paper›PMID 33100707›Full record

ArticleIndian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2020

The Prognostic Significance of the BMI-1 and BAALC Genes in Adult Patients with Acute Myeloid Leukemia.

Nevine F Shafik, Mona S El Ashry, Ragia H Badawy, Marwa M Hussein, Naglaa M Hassan

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Article in Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Nevine F ShafikDepartment of Clinical Pathology, National Cancer Institute (NCI), Cairo University, Fom Elkhalig, Kasr elaini street, Cairo, 11796 Egypt.
Mona S El AshryDepartment of Clinical Pathology, National Cancer Institute (NCI), Cairo University, Fom Elkhalig, Kasr elaini street, Cairo, 11796 Egypt.
Ragia H BadawyDepartment of Clinical Pathology, National Cancer Institute (NCI), Cairo University, Fom Elkhalig, Kasr elaini street, Cairo, 11796 Egypt.
Marwa M HusseinDepartment of Medical Oncology, National Cancer Institute (NCI), Cairo University, Cairo, 11796 Egypt.
Naglaa M HassanDepartment of Clinical Pathology, National Cancer Institute (NCI), Cairo University, Fom Elkhalig, Kasr elaini street, Cairo, 11796 Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this work is to investigate the different expression patterns of B cell-specifics moloney murine Leukemia virus integration site-1 (BMI-1) and brain and acute leukemia, cytoplasmic (BAALC) genes, their prognostic and clinical significance in newly diagnosed cytogenetically heterogenous adult acute myeloid leukemia patients. BMI-1 and BAALC expression was detected in the bone marrow of patients using quantitative real-time reverse transcription polymerase chain reaction with cut off value set at 50th percentile for both genes. BMI-1 and BAALC overexpression was detected in 50% of cases which suggest their potential as molecular markers. A statistical significant correlation was found between BMI-1 expression with hepatomegaly (

Indexed as

Acute myeloid leukemiaAMLBAALCB-cell-specifics moloney murine Leukemia virus integration site-1BMI-1Brain and acute leukemia cytoplasmicOverall survivalPrognosis

Identifiers

PMID33100707
PMCPMC7573057

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.