Evidence map›Paper›PMID 33100483›Full record

ArticleInterdisciplinary science reviews : ISR2020

Information, programme, signal: dead metaphors that negate the agency of organisms.

Ana M Soto, Carlos Sonnenschein

Abstract read
In one paragraph

Article in Interdisciplinary science reviews : ISR, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ana M SotoDepartment of Immunology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA.ORCID 0000-0002-9843-1903
Carlos SonnenscheinDepartment of Immunology, Tufts University School of Medicine, 136 Harrison Ave, Boston, MA 02111, USA.ORCID 0000-0003-3475-6423

Funding

Mechanisms of developmental toxicity of Bisphenol-AR01ES008314 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 1996 to 2016
$6.8M
BPA effects on the gut microbiomeR21ES026283 · NIEHS · TUFTS UNIVERSITY BOSTON · PI RUBIN, BEVERLY S, SOTO, ANA · 2016 to 2017
$454k
Development in a dish: an ex-vivo fetal mammary assay for toxicological researchUH2ES030045 · NIEHS · TUFTS UNIVERSITY BOSTON · PI SOTO, ANA · 2019 to 2020
$454k
NIEHS NIH HHS R01 ES008314NIEHS NIH HHS R21 ES026283NIEHS NIH HHS UH2 ES030045
6 · The paper itself

Abstract

The metaphorical adoption of the concepts of information, program and signal introduced into biology the logic and implicit causal structure of the mathematical theories of information; this is inimical to biology. In turn, those metaphors have hindered the development of a theory of organisms by transferring the agency of organisms to natural selection and to DNA. Moreover, those metaphors introduced into biology the dualism software-hardware and a Laplacian causal structure. Instead, we propose to uphold the agency of the living by adopting three foundational principles for a theory of organisms: namely, 1) the principle of biological inertia (i.e., the default state of cells is proliferation and motility), 2) the principle of variation, and 3) the principle of organization.

Indexed as

agencybiological inertiadefault statenormativityorganicismorganizationtheory of organismsvariation

Identifiers

PMID33100483
PMCPMC7577589

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.