Evidence map›Paper›PMID 33100144›Full record

ArticleTissue barriers2020

Environmental stressors affect intestinal permeability and repair responses in a pig intestinal ischemia model.

Amanda L Ziegler, Tiffany A Pridgen, Anthony T Blikslager

Open access · hybridAbstract read
In one paragraph

Article in Tissue barriers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Gut Health and Influencing Factors in Pigs.Animals : an open access journal from MDPI · 2023
    Review
  2. Age-Dependent Intestinal Repair: Implications for Foals with Severe Colic.Animals : an open access journal from MDPI · 2021
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Amanda L ZieglerNorth Carolina State University, College of Veterinary Medicine , Department of Clinical Sciences, Raleigh, NC, USA.ORCID 0000-0003-4450-0536
Tiffany A PridgenNorth Carolina State University, College of Veterinary Medicine , Department of Clinical Sciences, Raleigh, NC, USA.
Anthony T BlikslagerNorth Carolina State University, College of Veterinary Medicine , Department of Clinical Sciences, Raleigh, NC, USA.ORCID 0000-0002-0867-7310
North Carolina State University · US

Funding

PILOT AND FEASIBILITY STUDIESP30DK034987 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Temitope O. Keku · 1985 to 2026
$30.5M
Post-natal development of enteric glial cell-epithelial interactions in repair of ischemic-injured intestineR01HD095876 · NICHD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI BLIKSLAGER, ANTHONY, ODLE, JACK · 2019 to 2023
$1.8M
Postnatal development of intestinal barrier repairK01OD028207 · OD · NORTH CAROLINA STATE UNIVERSITY RALEIGH · PI ZIEGLER, AMANDA LEE · 2019 to 2023
$647k
NICHD NIH HHS R01 HD095876NIDDK NIH HHS P30 DK034987NIH HHS K01 OD028207NIH HHS L40 OD028437
6 · The paper itself

Abstract

The pig is a powerful model for intestinal barrier studies, and it is important to carefully plan animal care and handling for optimal study design as psychological and physiological stressors significantly impact intestinal mucosal barrier function. Here, we report the effects of a period of environmental acclimation versus acute transport stress on mucosal barrier repair after intestinal ischemic injury. Jejunal ischemia was induced in young pigs which had been allowed to acclimate to a biomedical research housing environment or had been transported immediately prior to experimental injury (non-acclimated). Mucosa was then incubated

Indexed as

AnimalsDisease Models, AnimalHumansIntestinesIschemiaPermeabilitySwineIntestinal barrierischemiapig modelstresstight junctions

Identifiers

PMID33100144
PMCPMC7714481
OpenAlexW3093572148

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.