Evidence map›Paper›PMID 33100129›Full record

ArticleTissue barriers2020

The intestinal quorum sensing 3-oxo-C12:2 Acyl homoserine lactone limits cytokine-induced tight junction disruption.

Doriane Aguanno, Garance Coquant, Barbara G Postal, Céline Osinski, Margaux Wieckowski, Daniel Stockholm, Jean-Pierre Grill, Véronique Carrière, Philippe Seksik, Sophie Thenet

Open access · hybridAbstract read
In one paragraph

Article in Tissue barriers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
  3. Gut microbes · 2025
    Article
  4. Review
  5. Article
  6. Conversations in the Gut: The Role of Quorum Sensing in Normobiosis.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Article
  9. Review
  10. Special Issue on the "Regulation and Physiopathology of the Gut Barrier".International journal of molecular sciences · 2022
    Article
  11. Article
  12. Review
  13. BioMed research international · 2022
    Review
  14. Review
  15. Article
  16. Review
  17. Inhibitory Effects of Artificial Sweeteners on Bacterial Quorum Sensing.International journal of molecular sciences · 2021
    Article
  18. Article
  19. Anti-Inflammatory Effects of Analogues ofInternational journal of molecular sciences · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Doriane AguannoCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.
Garance CoquantCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.
Barbara G PostalCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.ORCID 0000-0002-6505-2018
Céline OsinskiSorbonne Université, INSERM, Nutrition and obesities: systemic approaches , Paris, France.ORCID 0000-0003-4897-8510
Margaux WieckowskiCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.
Daniel StockholmCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.ORCID 0000-0002-5069-5256
Jean-Pierre GrillCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.
Véronique CarrièreCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.ORCID 0000-0002-6263-0847
Philippe SeksikCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.
Sophie ThenetCentre de Recherche Saint-Antoine, Sorbonne Université, INSERM , Paris, France.ORCID 0000-0002-0336-2942
Inserm · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The intestine is home to the largest microbiota community of the human body and strictly regulates its barrier function. Tight junctions (TJ) are major actors of the intestinal barrier, which is impaired in inflammatory bowel disease (IBD), along with an unbalanced microbiota composition. With the aim to identify new actors involved in host-microbiota interplay in IBD, we studied N-acyl homoserine lactones (AHL), molecules of the bacterial

Indexed as

Acyl-ButyrolactonesCytokinesHumansQuorum SensingTight JunctionsAcyl-ButyrolactonesCytokinesinflammatory bowel diseaseintestinal barrieritchleak pathwayN-(3-Oxododecanoyl)-L-homoserine lactoneN-acyl homoserine lactonesoccludinquorum sensingtight junctionstricellulin

Identifiers

PMID33100129
PMCPMC7714502
OpenAlexW3093922531

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.