ArticleEpigenetics2021
A Comparison of the Predictive Power of DNA Methylation with Carbohydrate Deficient Transferrin for Heavy Alcohol Consumption.
Article in Epigenetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed.
- Relationship intervention moderates the association between substance use and biological aging among Black adults.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2025Trial
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- Childhood exposure to danger increases Black youths' alcohol consumption, accelerated aging, and cardiac risk as young adults: A test of the incubation hypothesis.Development and psychopathology · 2025Article
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- Two Clinically Implementable Digital PCR Assessments of DNA Methylation for Diagnosing Heavy Alcohol Consumption.Epigenomes · 2024Review
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- Heavy alcohol consumption but not smoking predicts mortality in patients with acute coronary syndrome.Epigenetics · 2024Article
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- Hazardous drinking and alcohol use disorders.Nature reviews. Disease primers · 2022Review
- Digital methylation assessments of alcohol and cigarette consumption account for common variance in accelerated epigenetic ageing.Epigenetics · 2022Article
- Article
- Do Loneliness and Per Capita Income Combine to Increase the Pace of Biological Aging for Black Adults across Late Middle Age?International journal of environmental research and public health · 2022Article
- RNA biomarkers for alcohol use disorder.Frontiers in molecular neuroscience · 2022Review
- Article
- A simple, rapid, interpretable, actionable and implementable digital PCR based mortality index.Epigenetics · 2021Article
- Epigenetic Analyses of Alcohol Consumption in Combustible and Non-Combustible Nicotine Product Users.Epigenomes · 2021Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Currently, the most commonly used biomarker of alcohol consumption patterns is carbohydrate-deficient transferrin (CDT). However, the CDT has limited sensitivity and requires the use of blood. Recently, we have shown that digital DNA methylation techniques can both sensitively and specifically detect heavy alcohol consumption (HAC) using DNA from blood or saliva. In order to better understand the relative performance characteristics of these two tests, we compared an Alcohol T-Score (ATS) derived from our prior study and serum CDT levels in 313 (182 controls and 131 HAC cases) subjects discordant for HAC. Overall, the Receiver Operating Characteristic (ROC) area under the curve (AUC) analyses showed that DNA methylation predicted HAC status better than CDT with AUCs of 0.96 and 0.87, respectively (p < 0.0001). The performance of the CDT was affected by gender while the ATS was not, while both were affected by age. We conclude that DNA methylation is a promising method for quantifying HAC and that further studies to better refine its strengths and limitations are in order.
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