Evidence map›Paper›PMID 33100030›Full record

ArticleJournal of diabetes science and technology2022

Adjustment of Insulin Pump Settings in Type 1 Diabetes Management: Advisor Pro Device Compared to Physicians' Recommendations.

Revital Nimri, Tal Oron, Ido Muller, Ivana Kraljevic, Montserrat Martín Alonso, Paivi Keskinen, Tanja Milicic, Asaf Oren, Athanasios Christoforidis, Marieke den Brinker and 11 more

Open access · bronzeAbstract read
In one paragraph

Article in Journal of diabetes science and technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 39 citations in OpenAlex.

  1. Trial
  2. Review
  3. Review
  4. Diabetes management in the era of artificial intelligence.Archives of medical sciences. Atherosclerotic diseases · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Updates of precision medicine in type 2 diabetes.Cambridge prisms. Precision medicine · 2023
    Review
  9. Diabetes Technology Meeting 2021.Journal of diabetes science and technology · 2022
    Article
  10. Review
  11. Diabetes Technology Meeting 2020.Journal of diabetes science and technology · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 16 institutions in 11 countries.

Revital NimriThe Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah, Tikva, Israel.ORCID 0000-0003-3571-4938
Tal OronThe Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah, Tikva, Israel.
Ido MullerDreaMed Diabetes Ltd, Petah Tiqva, Israel.
Ivana KraljevicDepartment of Endocrinology and Diabetes, UHC Zagreb, School of Medicine, University of Zagreb, Zagreb, Croatia.
Montserrat Martín AlonsoDepartment of Pediatrics, Children's Endocrinology Unit, University Hospital of Salamanca, Spain.
Paivi KeskinenDepartment of Pediatrics, University Hospital of Tampere, Finland.
Tanja MilicicClinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine University of Belgrade, Serbia.
Asaf OrenPediatric Endocrinology and Diabetes Unit, Dana-Dwek Children's Hospital, Tel Aviv Sourasky Medical Center, Israel.
Athanasios ChristoforidisPediatric Department, Aristotle University of Thessaloniki, Hippokratio General Hospital, Thessaloniki, Greece.
Marieke den BrinkerDepartment of Pediatrics, Division of Pediatric Endocrinology and Diabetology, Antwerp University Hospital and University of Antwerp, Belgium.
Lutgarda BozzettoDepartment of Clinical Medicine and Surgery, University of Naples "Federico II", Italy.
Andrea Mario BollaDiabetes Research Institute, IRCCS San Raffaele Hospital, Milan, Italy.
Michal KrcmaDepartment of Internal Medicine, Diabetes and Endocrinology Unit, University Hospital Pilsen, Faculty of Medicine in Pilsen, Charles University, Czech Republic.ORCID 0000-0002-1564-2503
Rosa Anna RabiniDepartment of Diabetology, Hospital Mazzoni, Ascoli Piceno, Italy.
Shadi TabbaChildren's Hospital of the King's Daughters, Eastern Virginia Medical School, Norfolk, VA, USA.
Lizl SmithDepartment of Internal Medicine, Division of Endocrinology, University of Pretoria, South Africa.
Andriani VazeouA' Department of Pediatrics, Diabetes Center, P&A Kyriakou, Athens, Greece.
Giulio MaltoniDepartment of Pediatrics, University Hospital of Bologna Sant'Orsola-Malpighi Polyclinic, Italy.
Elisa GianiDepartment of Biomedical Sciences, Humanitas Clinical and Research Center-IRCCS and Humanitas University, Milan, Italy.
Eran AtlasDreaMed Diabetes Ltd, Petah Tiqva, Israel.
Moshe PhillipThe Jesse Z and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah, Tikva, Israel.
Schneider Children's Medical Center · ILTel Aviv University · ILAristotle University of Thessaloniki · GRCharles University · CZEastern Virginia Medical School · USHumanitas University · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · ITPanagiotis & Aglaia Kyriakou Children's Hospital · GRTampere University Hospital · FIUniversidad de Salamanca · ESUniversity of Antwerp · BEUniversity of Belgrade · RSUniversity of Naples Federico II · ITUniversity of Pretoria · ZAUniversity of Zagreb · HRVita-Salute San Raffaele University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsTo compare insulin dose adjustments made by physicians to those made by an artificial intelligence-based decision support system, the Advisor Pro, in people with type 1 diabetes (T1D) using an insulin pump and self-monitoring blood glucose (SMBG).

methodsThis was a multinational, non-interventional study surveying 17 physicians from 11 countries. Each physician was asked to provide insulin dose adjustments for the settings of the pump including basal rate, carbohydrate-to-insulin ratios (CRs), and correction factors (CFs) for 15 data sets of pumps and SMBG of people with T1D (mean age 18.4 ± 4.8 years; eight females; mean glycated hemoglobin 8.2% ± 1.4% [66 ± 11mmol/mol]). The recommendations were compared among the physicians and between the physicians and the Advisor Pro. The study endpoint was the percentage of comparison points for which there was an agreement on the direction of insulin dose adjustments.

resultsThe percentage (mean ± SD) of agreement among the physicians on the direction of insulin pump dose adjustments was 51.8% ± 9.2%, 54.2% ± 6.4%, and 49.8% ± 11.6% for the basal, CR, and CF, respectively. The automated recommendations of the Advisor Pro on the direction of insulin dose adjustments were comparable )49.5% ± 6.4%, 55.3% ± 8.7%, and 47.6% ± 14.4% for the basal rate, CR, and CF, respectively( and noninferior to those provided by physicians. The mean absolute difference in magnitude of change between physicians was 17.1% ± 13.1%, 14.6% ± 8.4%, and 23.9% ± 18.6% for the basal, CR, and CF, respectively, and comparable to the Advisor Pro 11.7% ± 9.7%, 10.1% ± 4.5%, and 25.5% ± 19.5%, respectively, significant for basal and CR.

conclusionsConsiderable differences in the recommendations for changes in insulin dosing were observed among physicians. Since automated recommendations by the Advisor Pro were similar to those given by physicians, it could be considered a useful tool to manage T1D.

Indexed as

Diabetes Mellitus, Type 1PhysiciansAdolescentAdultArtificial IntelligenceBlood GlucoseBlood Glucose Self-MonitoringFemaleGlycated HemoglobinHumansHypoglycemic AgentsInsulinInsulin Infusion SystemsMaleYoung AdultBlood GlucoseGlycated HemoglobinHypoglycemic AgentsInsulinAdvisor Proautomated decision supportinsulin pump settings adjustmentsself-monitoring of blood glucosetype 1 diabetes

Identifiers

PMID33100030
PMCPMC8861776
OpenAlexW3093490556

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.