Evidence map›Paper›PMID 33099987›Full record

ArticlePsychiatry investigation2020

The Gene Polymorphism of VMAT2 Is Associated with Risk of Schizophrenia in Male Han Chinese.

Hongying Han, Xiaowei Xia, Huirong Zheng, Chongbang Zhao, Yanming Xu, Jiong Tao, Xianglan Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry investigation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Hongying HanDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xiaowei XiaDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Huirong ZhengGuangdong Mental Health Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Affiliated School of Medicine of South China University of Technology, Guangzhou, China.
Chongbang ZhaoDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yanming XuDepartment of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Jiong TaoDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Xianglan WangDepartment of Psychiatry, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Sun Yat-sen University · CNGuangdong Academy of Medical Sciences · CNThird Affiliated Hospital of Sun Yat-sen University · CNWest China Hospital of Sichuan University · CN

Funding

Science and Technology Program of Guangdong 2012B031800357
6 · The paper itself

Abstract

objectiveTo investigate the association between gene polymorphism of vesicular monoamine transporter type 2(VMAT2) and schizophrenia in Han Chinese population.

methods430 patients with schizophrenia and 470 age-sex matched controls were recruited from four mental health centers. All patients were diagnosed by two psychiatrists based on the Structured Clinical Interview for DSM Disorders (SCID). The ligase detection reactions (LDR) method was used to assess the polymorphism of the two SNPs (rs363371 and rs363324) of VMAT2.

resultsNo associations of two SNPs with schizophrenia was found. When we stratified males and females for the analysis, we found that that in the recessive model of rs363371, there was an obvious significant association between rs363371 and schizophrenia in males (OR=0.564, 95% CI=0.357-0.892, p=0.014) but not females. For the association between rs363324 and schizophrenia, no association was found in either males or females. No association was found when stratifying early-onset schizophrenia and late-onset schizophrenia.

conclusionOur findings indicate that both rs363371 and rs363324 were not associated with schizophrenia, while it seemed that the AA genotype of rs363371 plays a protective effect in male Chinese in developing schizophrenia.

Indexed as

Gene polymorphismHan ChineseMaleSchizophreniaVMAT2

Identifiers

PMID33099987
PMCPMC7711117
OpenAlexW3094357282

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.