SynthesisOrthopaedic surgery2020
Comparison of Kinematic Alignment and Mechanical Alignment in Total Knee Arthroplasty: A Meta-analysis of Randomized Controlled Clinical Trials.
Synthesis in Orthopaedic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- Kinematic Alignment Does Not Result in Clinically Important Improvements After TKA Compared With Mechanical Alignment: A Meta-analysis of Randomized Trials.Clinical orthopaedics and related research · 2025Pooled it
- Postoperative clinical outcomes for kinematically, restricted kinematically, or mechanically aligned total knee arthroplasty: a systematic review and network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2023Pooled it
- No significant difference in early clinical outcomes of custom versus off-the-shelf total knee arthroplasty: a systematic review and meta-analysis.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Pooled it
- Kinematic alignment versus mechanical alignment in primary total knee arthroplasty: an updated meta-analysis of randomized controlled trials.Journal of orthopaedic surgery and research · 2022Pooled it
- No differences in functional and clinical outcomes after rehabilitation between modified kinematic and mechanical alignment in total knee arthroplasty: A randomized controlled trial.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026Trial
- The Comparison between Mini-Subvastus Approach and Medial Parapatellar Approach in TKA: A Prospective Double-Blinded Randomized Controlled Trial.Orthopaedic surgery · 2022Trial
- The Coronal Plane Alignment of the Knee Classification May be Unreliable With Advanced Knee Arthritis.Arthroplasty today · 2026Article
- Kinematic Alignment in Total Knee Arthroplasty of Varus Knees Minimises Distal Ankle Compensatory Changes Compared with Mechanical Alignment.Journal of clinical medicine · 2026Article
- Robot-Assisted TKA for Varus Knees: Post Hoc Exploratory Analysis of Alignment Strategy and Deformity Severity.Journal of clinical medicine · 2026Article
- Alignment Philosophies in Total Knee Arthroplasty: A Comprehensive Narrative Review.Arthroplasty today · 2026Article
- Short-term Outcomes of Unrestricted Kinematic Alignment: Total Knee Arthroplasty With a Medial Pivot Implant: A Japanese Multicenter Study.Arthroplasty today · 2026Article
- INTRAOPERATIVE ASSESSMENT OF COMPONENTS IN NAVIGATED KNEE ARTHROPLASTY IN THE ELDERLY.Acta ortopedica brasileira · 2026Article
- Kinematic alignment in total knee arthroplasty restores the native anatomy, with a joint line parallel to the ground on a standing view.Journal of orthopaedics · 2025Article
- Accuracy of Robotic Surgical Assistant (ROSA®) Surgical Plan in Total Knee Arthroplasty.Cureus · 2025Article
- Letter to the Editor: Kinematic Alignment Does Not Result in Clinically Important Improvements After TKA Compared With Mechanical Alignment: A Meta-analysis of Randomized Trials.Clinical orthopaedics and related research · 2025Article
- Clinical outcomes of kinematically aligned medial pivot total knee arthroplasty: A systematic review and meta-analysis of current evidence.Journal of experimental orthopaedics · 2025Review
- Distribution of phenotypes of coronal plane alignment of the knees and functional phenotypes in the healthy young Iranian population: A cross-sectional study.Journal of experimental orthopaedics · 2025Article
- Biopsychosocial based machine learning models predict patient improvement after total knee arthroplasty.Scientific reports · 2025Article
- Image-based robotic (ROSAJournal of orthopaedic surgery and research · 2025Article
- A deep learning based automatic two-dimensional digital templating model for total knee arthroplasty.Knee surgery & related research · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to estimate whether kinematic alignment (KA) improves knee function or clinical outcomes compared with mechanical alignment (MA) in the short term after total knee arthroplasty (TKA). We searched the literature for randomized controlled trials published before January 2020 from PubMed, EMBASE, Google, Web of Science, Cochrane Library, and other databases. The observation markers included "The Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index," "Knee Society Score (KSS)," "Oxford Knee Score (OKS)," "combined Knee Society Score (KSS)," "Knee injury and Osteoarthritis Outcome Score (KOOS)," "European Quality of Life Measure-5 Domain-5-Level (EQ-5D-5L)," range of motion (ROM), lower limb alignment, ligament release, and complications. A total of 11 randomized controlled trial studies were included in the study. During the follow-up of 6-24 months, the KA-TKA group was superior to the MA-TKA group in terms of WOMAC scores, combined KSS, KSS, knee function scores, and knee range of flexion, but there was no significant difference in EQ-5D-5L, KOOS, KOOS (symptoms, pain, ADL, sports, and quality of life), complications, knee range of extension, hip-knee-ankle (HKA) angle, tibial component slope angle, lateral distal femoral angle (LDFA) or medial proximal tibial angle (MPTA) angle between the MA-TKA group and the MA-TKA group (P > 0.05). Our meta-analysis revealed that the incidence of ligament release in the MA-TKA group was higher than that in the KA-TKA group. This meta-analysis shows that the KA-TKA group had better clinical outcomes and knee range of flexion than the MA-TKA group at short-term follow-up.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.