Evidence map›Paper›PMID 33099840›Full record

ArticleAmerican journal of reproductive immunology (New York, N.Y. : 1989)2021

Prospective association of maternal immune pro-inflammatory responsivity and regulation in pregnancy with length of gestation.

Lauren E Gyllenhammer, Sonja Entringer, Claudia Buss, Hyagriv N Simhan, William A Grobman, Emma K Adam, Lauren Keenan-Devlin, Ann E Borders, Pathik D Wadhwa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of reproductive immunology (New York, N.Y. : 1989), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Lauren E GyllenhammerDevelopment, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.
Sonja EntringerDevelopment, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.
Claudia BussDevelopment, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.
Hyagriv N SimhanDepartment of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
William A GrobmanDepartment of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Evanston, IL, USA.
Emma K AdamSchool of Education and Social Policy, Institute for Policy Research, Northwestern University, Evanston, IL, USA.
Lauren Keenan-DevlinDepartment of Obstetrics and Gynecology, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Ann E BordersDepartment of Obstetrics and Gynecology, NorthShore University Health System, University of Chicago Pritzker School of Medicine, Evanston, IL, USA.
Pathik D WadhwaDevelopment, Health and Disease Research Program, School of Medicine, University of California, Irvine, CA, USA.ORCID 0000-0002-4031-9337
University of California, Irvine · USNorthShore University HealthSystem · USNorthwestern University · USUniversity of Pittsburgh · US

Funding

Maternal Acculturation in Pregnancy and Infant Adiposity in Mexican AmericansR01MD010738 · NIMHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI ENTRINGER, SONJA, WADHWA, PATHIK D · 2016 to 2020
$3.6M
Social Disadvantage and Fetal Programming of Newborn-Infant Telomere BiologyR01AG050455 · NIA · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI EPEL, ELISSA S., SIMHAN, HYAGRIV N · 2016 to 2020
$3.0M
Synergistic effect of maternal insulin-resistance and cortisol in pregnancy on fetal programming of child mitochondrial function and obesity riskR00HD097302 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GYLLENHAMMER, LAUREN ELIZABETH · 2022 to 2024
$744k
Synergistic effect of maternal insulin-resistance and cortisol in pregnancy on fetal programming of child mitochondrial function and obesity riskK99HD097302 · NICHD · UNIVERSITY OF CALIFORNIA-IRVINE · PI GYLLENHAMMER, LAUREN ELIZABETH · 2019 to 2021
$272k
NIA NIH HHS AG-050455NIA NIH HHS R01 AG050455NICHD NIH HHS HHSN275201200007CNICHD NIH HHS K99 HD097302NICHD NIH HHS R00 HD097302NIMHD NIH HHS MD-010738NIMHD NIH HHS R01 MD010738
6 · The paper itself

Abstract

problemThe immune system represents a leading pathway of interest in the pathophysiology of preterm birth. The majority of human clinical studies interrogating this pathway have utilized circulating immune biomarkers; however, these concentrations typically reflect only basal production but not key functional properties of the immune system, particularly variation in the pro-inflammatory response to antigen challenge and the regulation of this response. Thus, in this study, we utilized an ex vivo stimulation protocol that quantifies these processes, and we examined their prospective association with the gestation length and risk of preterm birth. METHOD OF STUDY: Immune responsiveness and regulation were assessed in 128 pregnant women in mid-gestation using an ex vivo stimulation protocol. Maternal pro-inflammatory responsivity of leukocytes was quantified by assessing the release of the pro-inflammatory cytokines IL-6, TNF-α, and IL-1β in response to antigen stimulation, and regulation of the pro-inflammatory response was quantified by assessing the suppression of stimulated cytokine response upon co-incubation with increasing dexamethasone concentrations (ie, glucocorticoid receptor resistance; GRR).

resultsHigher maternal GRR, indicating impaired regulation of the pro-inflammatory response, was significantly and independently associated with shorter gestational length (β = -0.42, p = .0091) and a 3.0-fold increase in risk for preterm birth (OR = 3.01, 95% CI = 1.17-7.70, p = .0218). Basal circulating IL-6 and TNF-α were not associated with either outcome.

conclusionThe association of maternal GRR with length of gestation and preterm birth risk suggests that the processes represented by this measure-maternal pro-inflammatory propensity and immune regulation-may provide further mechanistic insight into the pathophysiology of preterm birth.

Indexed as

AdultCells, CulturedCytokinesDexamethasoneFemaleGlucocorticoidsHumansLeukocytesLipopolysaccharidesPregnancyPremature BirthReceptors, GlucocorticoidCytokinesDexamethasoneGlucocorticoidsLipopolysaccharidesReceptors, Glucocorticoidcortisolglucocorticoid resistanceinflammationinterleukin-1 betainterleukin-6length of gestationpreterm birthtumor necrosis factor

Identifiers

PMID33099840
PMCPMC10173805
OpenAlexW3093788719

What OpenQuestion holds

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Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.