Evidence map›Paper›PMID 33099753›Full record

ReviewHepatology international2020

Immunosuppressive regimens for adult liver transplant recipients in real-life practice: consensus recommendations from an Italian Working Group.

Umberto Cillo, Luciano De Carlis, Massimo Del Gaudio, Paolo De Simone, Stefano Fagiuoli, Francesco Lupo, Giuseppe Tisone, Riccardo Volpes

Erratum issuedOpen access · hybridAbstract readReviewConsensus Statement
In one paragraph

Review in Hepatology international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
7.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 60 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 8 institutions in 1 country.

Umberto CilloHepatobiliary and Liver Transplant Unit, University Hospital of Padua, Padua, Italy.
Luciano De CarlisDepartment of General Surgery and Transplantation, Niguarda Hospital, Milan, Italy.
Massimo Del GaudioDepartment of General Surgery and Transplantation, Policlinico S. Orsola-Malpighi, Bologna, Italy.
Paolo De SimoneHepatobiliary Surgery and Liver Transplantation Unit, University of Pisa Medical School Hospital, Pisa, Italy.
Stefano FagiuoliGastroenterology Hepatology and Transplantation, Papa Giovanni XXIII Hospital, Piazza OMS, 124127, Bergamo, Italy. sfagiuoli@asst-pg23.it.
Francesco LupoDepartment of General Surgery, Azienda Ospedaliera Città Della Salute E Della Scienza, Turin, Italy.
Giuseppe TisoneDepartment of Experimental Medicine and Surgery, Transplantation Surgery, Policlinico Tor Vergata University of Rome, Rome, Italy.
Riccardo VolpesMediterranean Institute for Transplantation and Advanced Specialized Therapies (ISMETT/IRCCS), Palermo, Italy.
Azienda Ospedaliera Citta' della Salute e della Scienza di Torino · ITAzienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda · ITIstituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione · ITOspedale Papa Giovanni XXIII · ITPoliclinico S.Orsola-Malpighi · ITPoliclinico Tor Vergata · ITUniversity of Padua · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is a well-recognized fact that implementing new guidelines in clinical practice may be difficult; therefore the Italian Society for Organ and Tissue Transplantation (SITO) set out to define practical immunosuppression tools for the management of liver transplantation patients. In 2017, an Italian Working Group of liver transplant experts and hepatologists issued a set of consensus statements along with evidence-based recommendations on the use of everolimus after liver transplantation. This article presents the evidence- and consensus-based algorithms developed within the Italian Working Group, which are aimed towards guiding clinicians in the selection of immunosuppressive regimens for the management of adult liver transplant recipients in real-life practice. The liver transplant recipient population, typically managed in clinical practice, was divided into the following categories: (1) standard patients; (2) critically ill patients; (3) patients with a specific etiology; (4) patients with hepatocellular carcinoma; (5) and patients with de novo malignancies. The algorithms are divided into two parts, according to the time from transplantation (0-3 months and > 3 months) and are discussed here along with relevant supporting literature, when available. Ultimately, it is hoped that the evidence- and consensus-based algorithms developed within the Italian Working Group, and presented here, contribute to simplify, personalize, and optimize immunosuppression of liver transplantation recipients in clinical practice.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsLiver TransplantationAdultHumansImmunosuppressive AgentsItalyTransplant RecipientsImmunosuppressive AgentsCalcineurin inhibitorChronic kidney diseaseConsensus recommendationsEverolimusHepatocellular carcinomaImmunosuppressionmTOR inhibitorSirolimusSolid-organ transplantationTacrolimus

Identifiers

PMID33099753
PMCPMC7803715
OpenAlexW3094380168

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.